21 cities
| City | County | 2025 Pop. ↓ |
|---|---|---|
| Hilton Head Island | Beaufort County | 38,301 |
| Hanahan | Berkeley County | 22,333 |
| Hardeeville | Jasper County | 15,394 |
| Homeland Park | Anderson County | 7,740 |
| Hartsville | Darlington County | 7,340 |
| Hollywood | Charleston County | 5,555 |
| Hilltop | Spartanburg County | 4,066 |
| Honea Path | Anderson County | 3,933 |
| Hampton | Hampton County | 2,577 |
| Homewood | Horry County | 1,612 |
| Hopkins | Richland County | 1,452 |
| Holly Hill | Orangeburg County | 1,250 |
| Hamer | Dillon County | 950 |
| Heath Springs | Lancaster County | 878 |
| Harleyville | Dorchester County | 757 |
| Helena | Newberry County | 605 |
| Hickory Grove | York County | 472 |
| Hemingway | Williamsburg County | 457 |
| Hilda | Barnwell County | 421 |
| Harbor Island | Beaufort County | 346 |
| Hodges | Greenwood County | 165 |