Santo Domingo's 2026 population is now estimated at 3,706,050. In 1950, the population of Santo Domingo was 180,283. Santo Domingo has grown by 57,940 in the last year, which represents a 1.59% annual change. These population estimates and projections come from the latest revision of the UN World Urbanization Prospects . These estimates represent the Urban agglomeration of Santo Domingo, which typically includes Santo Domingo's population in addition to adjacent suburban areas.