| City | State | 2026 Pop. ↓ | Annual Change | Rank | Type |
|---|---|---|---|---|---|
| Boston | Massachusetts | 671,635 | -0.2% | 1 | City |
| Worcester | Massachusetts | 215,778 | 0.9% | 2 | City |
| Providence | Rhode Island | 196,192 | 0.45% | 3 | City |
| Springfield | Massachusetts | 155,014 | 0.2% | 4 | City |
| Bridgeport | Connecticut | 153,208 | 0.61% | 5 | City |
| New Haven | Connecticut | 140,916 | 1.54% | 6 | City |
| Stamford | Connecticut | 140,509 | 0.7% | 7 | City |
| Cambridge | Massachusetts | 123,339 | 0.61% | 8 | City |
| Hartford | Connecticut | 122,321 | 0.28% | 9 | City |
| Lowell | Massachusetts | 119,847 | -0.1% | 10 | City |
| Manchester | New Hampshire | 117,453 | 0.54% | 11 | City |
| Waterbury | Connecticut | 116,177 | 0.35% | 12 | City |
| Brockton | Massachusetts | 106,078 | -0.05% | 13 | City |
| Lynn | Massachusetts | 104,710 | 0.45% | 14 | City |
| Quincy | Massachusetts | 103,699 | 0.51% | 15 | City |
| New Bedford | Massachusetts | 102,044 | 0.21% | 16 | City |
| Fall River | Massachusetts | 95,563 | 0.28% | 17 | City |
| Norwalk | Connecticut | 95,205 | 0.74% | 18 | City |
| Nashua | New Hampshire | 92,949 | 0.56% | 19 | City |
| Newton | Massachusetts | 91,483 | 0.82% | 20 | City |
| Danbury | Connecticut | 89,744 | 0.8% | 21 | City |
| Lawrence | Massachusetts | 89,147 | -0.19% | 22 | City |
| Cranston | Rhode Island | 85,026 | 0.45% | 23 | City |
| Somerville | Massachusetts | 84,334 | 0.15% | 24 | City |
| Warwick | Rhode Island | 84,327 | 0.17% | 25 | City |
| Pawtucket | Rhode Island | 77,403 | 0.44% | 26 | City |
| New Britain | Connecticut | 76,969 | 0.9% | 27 | City |
| Framingham | Massachusetts | 72,952 | -0.09% | 28 | City |
| Portland | Maine | 70,070 | 0.23% | 29 | City |
| Plymouth | Massachusetts | 68,758 | 1.34% | 30 | Town |
| Haverhill | Massachusetts | 68,306 | -0.08% | 31 | City |
| Fairfield | Connecticut | 66,622 | 0.54% | 32 | Township |
| Malden | Massachusetts | 66,362 | -0.01% | 33 | City |
| Greenwich | Connecticut | 64,960 | 0.25% | 34 | Township |
| Waltham | Massachusetts | 64,896 | -0.22% | 35 | City |
| West Hartford | Connecticut | 64,694 | 0.7% | 36 | Township |
| Brookline | Massachusetts | 63,421 | 0.01% | 37 | Town |
| Taunton | Massachusetts | 62,837 | 0.5% | 38 | City |
| Bristol | Connecticut | 62,686 | 0.55% | 39 | City |
| Hamden | Connecticut | 61,729 | -0.15% | 40 | Township |
| Meriden | Connecticut | 60,871 | 0.1% | 41 | City |
| Revere | Massachusetts | 59,907 | -0.39% | 42 | City |
| Manchester | Connecticut | 59,888 | 0.19% | 43 | Township |
| Medford | Massachusetts | 59,790 | -0.07% | 44 | City |
| Weymouth Town | Massachusetts | 59,779 | 0.03% | 45 | City |
| Everett | Massachusetts | 55,934 | 4.41% | 46 | City |
| Peabody | Massachusetts | 55,927 | -0.05% | 47 | City |
| Chicopee | Massachusetts | 55,329 | 0.03% | 48 | City |
| West Haven | Connecticut | 55,318 | -0.06% | 49 | City |
| Stratford | Connecticut | 54,071 | 0.3% | 50 | Township |
| East Hartford | Connecticut | 51,022 | 0.11% | 51 | Township |
| Barnstable Town | Massachusetts | 50,134 | 0.07% | 52 | City |
For this list, the New England Region is defined as the 6 states of Connecticut, Maine, Massachusetts, New Hampshire, Rhode Island and Vermont.