| City | State | 2026 Pop. ↓ | Annual Change | Rank | Type |
|---|---|---|---|---|---|
| Houston | Texas | 2,419,191 | 0.91% | 1 | City |
| Phoenix | Arizona | 1,677,947 | 0.75% | 2 | City |
| San Antonio | Texas | 1,572,360 | 1.55% | 3 | City |
| Dallas | Texas | 1,336,440 | 0.52% | 4 | City |
| Fort Worth | Texas | 1,049,355 | 2.07% | 5 | City |
| Austin | Texas | 1,011,743 | 0.91% | 6 | City |
| Oklahoma City | Oklahoma | 727,550 | 1.07% | 7 | City |
| El Paso | Texas | 684,495 | 0.22% | 8 | City |
| Albuquerque | New Mexico | 555,119 | -0.26% | 9 | City |
| Tucson | Arizona | 550,374 | 0.37% | 10 | City |
| Mesa | Arizona | 515,855 | 0.43% | 11 | City |
| Tulsa | Oklahoma | 416,850 | 0.15% | 12 | City |
| Arlington | Texas | 404,380 | 0.56% | 13 | City |
| Corpus Christi | Texas | 316,964 | -0.09% | 14 | City |
| Plano | Texas | 294,773 | 0.6% | 15 | City |
| Gilbert | Arizona | 291,713 | 1.54% | 16 | Town |
| Chandler | Arizona | 279,399 | 0.23% | 17 | City |
| Lubbock | Texas | 276,107 | 1.11% | 18 | City |
| Laredo | Texas | 272,832 | 1.23% | 19 | City |
| Glendale | Arizona | 262,540 | 0.76% | 20 | City |
| Irving | Texas | 257,513 | 0.17% | 21 | City |
| Garland | Texas | 250,791 | 0.47% | 22 | City |
| Frisco | Texas | 245,057 | 3.42% | 23 | City |
| Scottsdale | Arizona | 243,713 | 0.29% | 24 | City |
| McKinney | Texas | 243,498 | 3.18% | 25 | City |
| Grand Prairie | Texas | 212,266 | 1.35% | 26 | City |
| Amarillo | Texas | 205,871 | 0.36% | 27 | City |
| Peoria | Arizona | 202,571 | 0.84% | 28 | City |
| Brownsville | Texas | 194,415 | 0.76% | 29 | City |
| Tempe | Arizona | 191,590 | 0.53% | 30 | City |
| Surprise | Arizona | 181,107 | 3.31% | 31 | City |
| Denton | Texas | 175,704 | 3.7% | 32 | City |
| Killeen | Texas | 163,533 | 1.02% | 33 | City |
| McAllen | Texas | 152,205 | 1.04% | 34 | City |
| Mesquite | Texas | 150,903 | 0.14% | 35 | City |
| Midland | Texas | 150,351 | 1.85% | 36 | City |
| Waco | Texas | 149,350 | 1.06% | 37 | City |
| Pasadena | Texas | 148,007 | -0.36% | 38 | City |
| Round Rock | Texas | 145,048 | 2.67% | 39 | City |
| Lewisville | Texas | 141,416 | 1.73% | 40 | City |
| Carrollton | Texas | 135,107 | 0.41% | 41 | City |
| Abilene | Texas | 132,823 | 0.94% | 42 | City |
| Buckeye | Arizona | 131,812 | 5.08% | 43 | City |
| Norman | Oklahoma | 131,616 | 0.51% | 44 | City |
| Pearland | Texas | 130,677 | 0.57% | 45 | City |
| Goodyear | Arizona | 130,332 | 3.97% | 46 | City |
| College Station | Texas | 129,076 | 1.26% | 47 | City |
| New Braunfels | Texas | 128,712 | 5.08% | 48 | City |
| Broken Arrow | Oklahoma | 127,206 | 1.77% | 49 | City |
| Conroe | Texas | 125,440 | 4.91% | 50 | City |
| Odessa | Texas | 124,023 | 1.07% | 51 | City |
| The Woodlands | Texas | 122,240 | 1.47% | 52 | CDP |
| League City | Texas | 120,814 | 0.76% | 53 | City |
| Richardson | Texas | 118,205 | -0.28% | 54 | City |
| Las Cruces | New Mexico | 118,133 | 0.99% | 55 | City |
| Rio Rancho | New Mexico | 116,418 | 1.75% | 56 | City |
| Allen | Texas | 115,492 | 1.8% | 57 | City |
| Tyler | Texas | 115,314 | 1.4% | 58 | City |
| Georgetown | Texas | 115,088 | 7.65% | 59 | City |
| Edinburg | Texas | 112,735 | 1.84% | 60 | City |
| Beaumont | Texas | 112,524 | -0.39% | 61 | City |
| San Tan Valley | Arizona | 110,749 | 1.69% | 62 | CDP |
| Sugar Land | Texas | 107,255 | -0.44% | 63 | City |
| Yuma | Arizona | 106,923 | 1.61% | 64 | City |
| Avondale | Arizona | 102,760 | 1.76% | 65 | City |
| Wichita Falls | Texas | 101,849 | -0.1% | 66 | City |
| Temple | Texas | 101,765 | 3.41% | 67 | City |
| Edmond | Oklahoma | 101,571 | 1.09% | 68 | City |
| San Angelo | Texas | 100,702 | 0.06% | 69 | City |
| Atascocita | Texas | 100,406 | 2.2% | 70 | CDP |
| Leander | Texas | 97,835 | 7.36% | 71 | City |
| Queen Creek | Arizona | 95,338 | 6.2% | 72 | Town |
| Bryan | Texas | 93,704 | 1.86% | 73 | City |
| Santa Fe | New Mexico | 90,468 | 0.7% | 74 | City |
| Lawton | Oklahoma | 90,468 | -0.04% | 75 | City |
| Mission | Texas | 89,647 | 0.74% | 76 | City |
| Baytown | Texas | 86,670 | 0.13% | 77 | City |
| Mansfield | Texas | 86,408 | 2.33% | 78 | City |
| Longview | Texas | 83,652 | 0.5% | 79 | City |
| Maricopa | Arizona | 82,372 | 5.12% | 80 | City |
| Pharr | Texas | 81,130 | 0.37% | 81 | City |
| Flower Mound | Texas | 80,415 | 1.1% | 82 | Town |
| San Marcos | Texas | 79,808 | 2.54% | 83 | City |
| Cedar Park | Texas | 79,172 | 0.18% | 84 | City |
| Missouri City | Texas | 78,207 | 1.14% | 85 | City |
| Flagstaff | Arizona | 77,317 | 0.07% | 86 | City |
| Kyle | Texas | 74,790 | 6.97% | 87 | City |
| Fulshear | Texas | 73,692 | 14.02% | 88 | City |
| Casa Grande | Arizona | 73,011 | 4.67% | 89 | City |
| Celina | Texas | 72,848 | 13.07% | 90 | City |
| Harlingen | Texas | 72,574 | 0.15% | 91 | City |
| Casas Adobes | Arizona | 71,687 | 0.43% | 92 | CDP |
| North Richland Hills | Texas | 71,122 | 0.39% | 93 | City |
| Spring | Texas | 70,058 | 1.43% | 94 | CDP |
| Rowlett | Texas | 69,243 | 1.99% | 95 | City |
| Pflugerville | Texas | 68,765 | 0.66% | 96 | City |
| Marana | Arizona | 67,860 | 3.57% | 97 | Town |
| Victoria | Texas | 66,676 | 0.26% | 98 | City |
| Little Elm | Texas | 66,237 | 5.6% | 99 | City |
| Wylie | Texas | 65,094 | 1.96% | 100 | City |
| Moore | Oklahoma | 63,775 | 0.26% | 101 | City |
| Texas City | Texas | 61,143 | 2.36% | 102 | City |
| Lake Havasu City | Arizona | 59,861 | 0.85% | 103 | City |
| Euless | Texas | 59,730 | -0.46% | 104 | City |
| Burleson | Texas | 59,034 | 3.74% | 105 | City |
| Midwest City | Oklahoma | 58,839 | 0.07% | 106 | City |
| DeSoto | Texas | 56,877 | 0.35% | 107 | City |
| Port Arthur | Texas | 55,792 | -0.02% | 108 | City |
| Rockwall | Texas | 55,420 | 2.67% | 109 | City |
| Sherman | Texas | 54,008 | 3.04% | 110 | City |
| Galveston | Texas | 53,623 | -0.02% | 111 | City |
| Prescott Valley | Arizona | 53,507 | 2.07% | 112 | Town |
| Catalina Foothills | Arizona | 51,978 | 0.14% | 113 | CDP |
| Waxahachie | Texas | 51,860 | 3.53% | 114 | City |
| Grapevine | Texas | 50,850 | 0.27% | 115 | City |
| Stillwater | Oklahoma | 50,415 | 0.74% | 116 | City |
| Enid | Oklahoma | 50,145 | -0.3% | 117 | City |
For this list, the Southwest Region is defined as the 4 states of Arizona, New Mexico, Oklahoma and Texas.