119 cities
| City | State | 2026 Pop. ↓ | Annual Change | Rank | Type |
|---|---|---|---|---|---|
| Houston | Texas | 2,435,715 | 0.94% | 1 | City |
| Phoenix | Arizona | 1,703,449 | 0.9% | 2 | City |
| San Antonio | Texas | 1,570,314 | 1.41% | 3 | City |
| Dallas | Texas | 1,337,417 | 0.43% | 4 | City |
| Fort Worth | Texas | 1,050,336 | 2.05% | 5 | City |
| Austin | Texas | 1,007,435 | 0.69% | 6 | City |
| Oklahoma City | Oklahoma | 727,836 | 1.04% | 7 | City |
| El Paso | Texas | 682,893 | 0.09% | 8 | City |
| Tucson | Arizona | 559,695 | 0.51% | 9 | City |
| Albuquerque | New Mexico | 558,046 | -0.2% | 10 | City |
| Mesa | Arizona | 522,751 | 0.54% | 11 | City |
| Tulsa | Oklahoma | 415,899 | 0.09% | 12 | City |
| Arlington | Texas | 408,318 | 0.57% | 13 | City |
| Corpus Christi | Texas | 316,833 | -0.08% | 14 | City |
| Gilbert | Arizona | 298,470 | 1.65% | 15 | Town |
| Plano | Texas | 296,718 | 0.58% | 16 | City |
| Chandler | Arizona | 283,132 | 0.34% | 17 | City |
| Lubbock | Texas | 279,104 | 1.27% | 18 | City |
| Laredo | Texas | 264,142 | 0.55% | 19 | City |
| Glendale | Arizona | 262,745 | 0.88% | 20 | City |
| Irving | Texas | 258,636 | 0.11% | 21 | City |
| Garland | Texas | 252,450 | 0.4% | 22 | City |
| Frisco | Texas | 251,430 | 3.33% | 23 | City |
| Scottsdale | Arizona | 248,321 | 0.44% | 24 | City |
| McKinney | Texas | 242,534 | 3.19% | 25 | City |
| Grand Prairie | Texas | 212,896 | 1.32% | 26 | City |
| Amarillo | Texas | 205,310 | 0.39% | 27 | City |
| Peoria | Arizona | 203,891 | 0.98% | 28 | City |
| Brownsville | Texas | 194,626 | 0.69% | 29 | City |
| Tempe | Arizona | 192,514 | 0.63% | 30 | City |
| Surprise | Arizona | 179,149 | 3.34% | 31 | City |
| Denton | Texas | 178,433 | 3.61% | 32 | City |
| Killeen | Texas | 164,045 | 1.06% | 33 | City |
| McAllen | Texas | 151,972 | 1.06% | 34 | City |
| Mesquite | Texas | 150,391 | 0.08% | 35 | City |
| Waco | Texas | 149,640 | 1.02% | 36 | City |
| Midland | Texas | 148,908 | 1.78% | 37 | City |
| Pasadena | Texas | 148,701 | -0.31% | 38 | City |
| Round Rock | Texas | 142,752 | 2.66% | 39 | City |
| Lewisville | Texas | 140,759 | 1.73% | 40 | City |
| Carrollton | Texas | 136,403 | 0.35% | 41 | City |
| Abilene | Texas | 133,136 | 1% | 42 | City |
| Norman | Oklahoma | 132,425 | 0.54% | 43 | City |
| College Station | Texas | 131,645 | 1.39% | 44 | City |
| Pearland | Texas | 131,424 | 0.69% | 45 | City |
| New Braunfels | Texas | 128,874 | 5.05% | 46 | City |
| Goodyear | Arizona | 128,372 | 4.13% | 47 | City |
| Broken Arrow | Oklahoma | 127,156 | 1.76% | 48 | City |
| Conroe | Texas | 126,254 | 4.85% | 49 | City |
| Buckeye | Arizona | 124,630 | 4.31% | 50 | City |
| The Woodlands | Texas | 122,240 | 1.47% | 51 | CDP |
| Odessa | Texas | 122,155 | 1% | 52 | City |
| League City | Texas | 120,354 | 0.79% | 53 | City |
| Las Cruces | New Mexico | 119,636 | 1.11% | 54 | City |
| Allen | Texas | 117,841 | 1.77% | 55 | City |
| Richardson | Texas | 117,677 | -0.23% | 56 | City |
| Georgetown | Texas | 117,660 | 7.45% | 57 | City |
| Rio Rancho | New Mexico | 116,565 | 1.76% | 58 | City |
| Tyler | Texas | 115,194 | 1.31% | 59 | City |
| Edinburg | Texas | 112,716 | 1.8% | 60 | City |
| Beaumont | Texas | 111,900 | -0.44% | 61 | City |
| San Tan Valley | Arizona | 110,749 | 1.69% | 62 | CDP |
| Sugar Land | Texas | 109,354 | -0.23% | 63 | City |
| Yuma | Arizona | 106,667 | 1.48% | 64 | City |
| Temple | Texas | 103,001 | 3.38% | 65 | City |
| Wichita Falls | Texas | 102,317 | -0.03% | 66 | City |
| Edmond | Oklahoma | 101,185 | 1.07% | 67 | City |
| Leander | Texas | 100,843 | 7.08% | 68 | City |
| Atascocita | Texas | 100,406 | 2.2% | 69 | CDP |
| San Angelo | Texas | 100,206 | 0.02% | 70 | City |
| Avondale | Arizona | 100,130 | 1.79% | 71 | City |
| Queen Creek | Arizona | 95,235 | 6.4% | 72 | Town |
| Bryan | Texas | 95,132 | 1.92% | 73 | City |
| Santa Fe | New Mexico | 91,957 | 0.77% | 74 | City |
| Mission | Texas | 89,929 | 0.76% | 75 | City |
| Lawton | Oklahoma | 89,853 | -0.1% | 76 | City |
| Baytown | Texas | 86,288 | 0.16% | 77 | City |
| Maricopa | Arizona | 85,553 | 5.49% | 78 | City |
| Mansfield | Texas | 84,801 | 2.41% | 79 | City |
| Longview | Texas | 84,616 | 0.56% | 80 | City |
| Pharr | Texas | 81,790 | 0.4% | 81 | City |
| Flower Mound | Texas | 81,739 | 1.08% | 82 | Town |
| Missouri City | Texas | 80,653 | 1.3% | 83 | City |
| Cedar Park | Texas | 78,551 | 0.11% | 84 | City |
| Flagstaff | Arizona | 77,763 | 0.14% | 85 | City |
| San Marcos | Texas | 77,362 | 2.01% | 86 | City |
| Casa Grande | Arizona | 76,327 | 5.09% | 87 | City |
| Kyle | Texas | 75,533 | 6.86% | 88 | City |
| Fulshear | Texas | 73,135 | 14.48% | 89 | City |
| Harlingen | Texas | 72,328 | 0.07% | 90 | City |
| North Richland Hills | Texas | 72,007 | 0.4% | 91 | City |
| Casas Adobes | Arizona | 71,687 | 0.43% | 92 | CDP |
| Rowlett | Texas | 70,800 | 1.93% | 93 | City |
| Spring | Texas | 70,058 | 1.43% | 94 | CDP |
| Celina | Texas | 68,583 | 14.07% | 95 | City |
| Little Elm | Texas | 68,222 | 5.41% | 96 | City |
| Pflugerville | Texas | 67,483 | 0.49% | 97 | City |
| Marana | Arizona | 67,257 | 3.76% | 98 | Town |
| Victoria | Texas | 66,262 | 0.18% | 99 | City |
| Wylie | Texas | 65,489 | 1.97% | 100 | City |
| Moore | Oklahoma | 64,239 | 0.31% | 101 | City |
| Texas City | Texas | 60,669 | 2.36% | 102 | City |
| Burleson | Texas | 60,379 | 3.54% | 103 | City |
| Lake Havasu City | Arizona | 59,871 | 0.7% | 104 | City |
| Euless | Texas | 59,475 | -0.45% | 105 | City |
| Midwest City | Oklahoma | 58,525 | 0.02% | 106 | City |
| DeSoto | Texas | 57,047 | 0.3% | 107 | City |
| Rockwall | Texas | 56,446 | 2.64% | 108 | City |
| Port Arthur | Texas | 55,693 | -0.1% | 109 | City |
| Prescott Valley | Arizona | 53,674 | 2.13% | 110 | Town |
| Galveston | Texas | 53,481 | -0.05% | 111 | City |
| Sherman | Texas | 53,364 | 3.03% | 112 | City |
| Waxahachie | Texas | 52,116 | 3.47% | 113 | City |
| Catalina Foothills | Arizona | 51,978 | 0.14% | 114 | CDP |
| Grapevine | Texas | 51,597 | 0.27% | 115 | City |
| Prosper | Texas | 51,345 | 7.14% | 116 | Town |
| Huntsville | Texas | 51,320 | 1.81% | 117 | City |
| Stillwater | Oklahoma | 51,012 | 0.86% | 118 | City |
| Enid | Oklahoma | 50,198 | -0.32% | 119 | City |
For this list, the Southwest Region is defined as the 4 states of Arizona, New Mexico, Oklahoma and Texas.