| City | County | 2025 Pop. ↓ |
|---|---|---|
| Clinton | Hinds County | 25,845 |
| Columbus | Lowndes County | 22,395 |
| Corinth | Alcorn County | 14,021 |
| Clarksdale | Coahoma County | 13,237 |
| Canton | Madison County | 10,626 |
| Cleveland | Bolivar County | 9,907 |
| Columbia | Marion County | 5,643 |
| Carthage | Leake County | 4,777 |
| Crystal Springs | Copiah County | 4,577 |
| Collins | Covington County | 2,231 |
| Cleary | Rankin County | 2,127 |
| Collinsville | Lauderdale County | 1,742 |
| Charleston | Tallahatchie County | 1,623 |
| Calhoun City | Calhoun County | 1,451 |
| Columbus AFB | Lowndes County | 1,442 |
| Coldwater | Tate County | 1,309 |
| Conehatta | Newton County | 1,214 |
| Centreville | Wilkinson County | 1,117 |
| Caledonia | Monroe County | 1,099 |
| Como | Panola County | 1,049 |
| Coffeeville | Yalobusha County | 762 |
| Clara | Wayne County | 644 |
| Crenshaw | Panola County | 603 |
| Cloverdale | Adams County | 550 |
| Crowder | Quitman County | 515 |
| Courtland | Panola County | 465 |
| Carrollton | Carroll County | 415 |
| Crawford | Lowndes County | 410 |
| Chunky | Newton County | 268 |
| Cary | Sharkey County | 236 |
| Cruger | Holmes County | 232 |
| Crosby | Amite County | 222 |
| Coahoma | Coahoma County | 210 |
| Chalybeate | Alcorn County | 14 |