Santo Domingo's 2025 population is now estimated at 3,648,110. In 1950, the population of Santo Domingo was 180,283. Santo Domingo has grown by 60,710 in the last year, which represents a 1.69% annual change. These population estimates and projections come from the latest revision of the UN World Urbanization Prospects . These estimates represent the Urban agglomeration of Santo Domingo, which typically includes Santo Domingo's population in addition to adjacent suburban areas.