Santiago Tuxtla's 2025 population is now estimated at 16,321. In 2000, the population of Santiago Tuxtla was 15,348. Santiago Tuxtla has grown by 408 in the last year, which represents a 0.36% annual change.
| City | 2025 Pop. ↓ | Growth |
|---|---|---|
| Mexico City | 22,752,400 | 1.1% |
| Guadalajara | 5,578,580 | 1.44% |
| Monterrey | 5,272,360 | 1.48% |
| Puebla | 3,443,290 | 1.44% |
| Toluca de Lerdo | 2,719,520 | 1.69% |
| Tijuana | 2,333,220 | 1.57% |
| Leon de los Aldamas | 1,950,390 | 1.35% |
| La Laguna | 1,866,580 | 2.21% |
| Ciudad Juarez | 1,625,980 | 1.36% |
| Queretaro | 1,459,290 | 1.56% |
| San Luis Potosi | 1,310,720 | 1.44% |
| Merida | 1,258,230 | 1.5% |
| Mexicali | 1,215,000 | 1.5% |
| Aguascalientes | 1,196,770 | 1.48% |
| Cuernavaca | 1,156,360 | 1.42% |
| Chihuahua | 1,153,540 | 1.6% |
| Tampico | 1,077,740 | 1.43% |
| Saltillo | 1,066,100 | 1.5% |
| Cancun | 1,065,400 | 1.95% |
| Acapulco de Juarez | 1,046,710 | 1.35% |
| Morelia | 1,016,230 | 1.37% |
| Reynosa | 983,121 | 1.6% |
| Veracruz | 981,069 | 1.34% |
| Villahermosa | 972,373 | 1.49% |
| Hermosillo | 944,348 | 1.55% |
| Tuxtla Gutierrez | 927,758 | 1.61% |
| Culiacan | 918,494 | 1.61% |
| Xalapa | 834,581 | 1.42% |
| Oaxaca de Juarez | 757,292 | 1.41% |
| Celaya | 727,242 | 1.34% |
| Pachuca de Soto | 692,702 | 1.6% |
| Durango | 686,982 | 1.55% |
| Tlaxcala | 646,056 | 1.5% |
| Matamoros | 603,693 | 1.39% |
| Tepic | 601,415 | 1.68% |
| Poza Rica de Hidalgo | 598,418 | 1.26% |
| Puerto Vallarta | 578,342 | 1.88% |
| Cuautla Morelos | 559,382 | 1.49% |
| Orizaba | 505,396 | 1.29% |
| Mazatlan | 492,400 | 1.49% |
| Irapuato | 489,703 | 1.49% |
| Nuevo Laredo | 480,636 | 1.42% |
| Colima | 447,305 | 1.58% |
| Minatitlan | 427,760 | 1.33% |
| Coatzacoalcos | 422,647 | 1.36% |
| Ciudad Obregon | 408,152 | 1.63% |
| Zacatecas | 399,033 | 1.49% |
| Ciudad Victoria | 391,988 | 1.48% |
| Monclova | 385,955 | 1.36% |
| Cordoba | 374,852 | 1.3% |
| Tehuacan | 366,948 | 1.39% |
| Ensenada | 363,194 | 1.51% |
| Uruapan | 361,722 | 1.63% |
| Los Mochis | 341,701 | 1.57% |