Valle de Santiago's 2025 population is now estimated at 74,962. In 2000, the population of Valle de Santiago was 58,837. Valle de Santiago has grown by 3,305 in the last year, which represents a 0.65% annual change.
| City | 2025 Pop. ↓ | Growth |
|---|---|---|
| Mexico City | 22,752,400 | 1.1% |
| Guadalajara | 5,578,580 | 1.43% |
| Monterrey | 5,272,360 | 1.48% |
| Puebla | 3,443,290 | 1.44% |
| Toluca de Lerdo | 2,719,520 | 1.69% |
| Tijuana | 2,333,220 | 1.57% |
| Leon de los Aldamas | 1,950,390 | 1.35% |
| La Laguna | 1,866,580 | 2.21% |
| Ciudad Juarez | 1,625,980 | 1.37% |
| Queretaro | 1,459,290 | 1.56% |
| San Luis Potosi | 1,310,720 | 1.44% |
| Merida | 1,258,230 | 1.5% |
| Mexicali | 1,215,000 | 1.51% |
| Aguascalientes | 1,196,770 | 1.48% |
| Cuernavaca | 1,156,360 | 1.42% |
| Chihuahua | 1,153,540 | 1.6% |
| Tampico | 1,077,740 | 1.43% |
| Saltillo | 1,066,100 | 1.5% |
| Cancun | 1,065,400 | 1.95% |
| Acapulco de Juarez | 1,046,710 | 1.35% |