There are 22 cities in Mississippi in the East region.
City | Rank | County | 2024 Pop. |
|---|---|---|---|
| Meridian | 1 | Clarke County | 33,112 |
| Philadelphia | 2 | Kemper County | 6,866 |
| Louisville | 3 | Winston County | 5,863 |
| Newton | 4 | Jasper County | 3,081 |
| Macon | 5 | Noxubee County | 2,420 |
| Union | 6 | Kemper County | 1,992 |
| Decatur | 7 | Newton County | 1,913 |
| Collinsville | 8 | Kemper County | 1,756 |
| Marion | 9 | Clarke County | 1,674 |
| Nellieburg | 10 | Lauderdale County | 1,306 |
| Brooksville | 11 | Noxubee County | 875 |
| De Kalb | 12 | Kemper County | 824 |
| Scooba | 13 | Kemper County | 721 |
| Toomsuba | 14 | Lauderdale County | 720 |
| Meridian Station | 15 | Lauderdale County | 468 |
| Hickory | 16 | Jasper County | 405 |
| Shuqualak | 17 | Kemper County | 377 |
| Noxapater | 18 | Neshoba County | 373 |
| Tucker | 19 | Kemper County | 328 |
| Chunky | 20 | Lauderdale County | 268 |
| Bogue Chitto | 21 | Kemper County | 224 |
| Lauderdale | 22 | Kemper County | 176 |