| Zip Code | City | Population ↓ |
|---|---|---|
| 19966 | Millsboro | 32,513 |
| 19958 | Lewes | 28,761 |
| 19973 | Seaford | 26,070 |
| 19963 | Milford | 21,394 |
| 19947 | Georgetown | 19,513 |
| 19956 | Laurel | 15,822 |
| 19968 | Milton | 15,125 |
| 19971 | Rehoboth Beach | 15,043 |
| 19933 | Bridgeville | 10,610 |
| 19975 | Selbyville | 9,693 |
| 19945 | Frankford | 8,519 |
| 19939 | Dagsboro | 7,668 |
| 19970 | Ocean View | 7,639 |
| 19950 | Greenwood | 7,524 |
| 19960 | Lincoln | 6,863 |
| 19940 | Delmar | 6,818 |
| 19941 | Ellendale | 3,109 |
| 19930 | Bethany Beach | 2,878 |
| 19951 | Harbeson | 2,173 |
| 19967 | Millville | 2,050 |
| 19944 | Fenwick Island | 582 |
| 19931 | Bethel | 376 |
The data shown reflect ZCTAs from the US Census. As of 2024, there are 22 ZCTAs in Sussex County, Delaware (US Census).