| Zip Code | City | Population ↓ |
|---|---|---|
| 41858 | Whitesburg | 7,473 |
| 41537 | Jenkins | 3,580 |
| 41840 | Neon | 1,187 |
| 41804 | Blackey | 1,066 |
| 41838 | Millstone | 1,031 |
| 41837 | Mayking | 1,014 |
| 41824 | Isom | 912 |
| 41855 | Thornton | 794 |
| 41815 | Ermine | 776 |
| 41835 | McRoberts | 728 |
| 41826 | Jeremiah | 701 |
| 40862 | Partridge | 606 |
| 40826 | Eolia | 482 |
| 41845 | Premium | 362 |
| 41832 | Letcher | 322 |
| 41810 | Cromona | 281 |
| 41819 | Gordon | 244 |
| 41825 | Jackhorn | 225 |
| 41812 | Deane | 201 |
| 41821 | Hallie | 180 |
| 41833 | Linefork | 140 |
| 41849 | Seco | 119 |
| 41517 | Burdine | 66 |
| 41848 | Roxana | 0 |
The data shown reflect ZCTAs from the US Census. As of 2024, there are 24 ZCTAs in Letcher County, Kentucky (US Census).