City | 2024 Population |
|---|---|
| Salem | 124 |
| Salley | 353 |
| Saluda | 3,053 |
| Sandy Springs | 772 |
| Sangaree | 8,111 |
| Sans Souci | 7,284 |
| Santee | 805 |
| Saxon | 4,499 |
| Scotia | 154 |
| Scranton | 655 |
| Seabrook | 718 |
| Seabrook Island | 2,119 |
| Sellers | 145 |
| Seneca | 9,105 |
| Seven Oaks | 16,356 |
| Sharon | 467 |
| Sheldon | 377 |
| Shell Point | 1,120 |
| Shiloh | 209 |
| Silverstreet | 167 |
| Simpsonville | 28,807 |
| Six Mile | 752 |
| Slater-Marietta | 2,300 |
| Smoaks | 97 |
| Smyrna | 57 |
| Snelling | 250 |
| Socastee | 24,078 |
| Society Hill | 428 |
| South Congaree | 2,388 |
| South Sumter | 1,182 |
| South Union | 434 |
| Southern Shops | 3,747 |
| Spartanburg | 39,184 |
| Springdale | 2,554 |
| Springfield | 430 |
| St. Andrews | 22,463 |
| St. Charles | 79 |
| St. George | 1,832 |
| St. Matthews | 1,822 |
| St. Stephen | 1,573 |
| Starr | 174 |
| Startex | 550 |
| Stateburg | 1,739 |
| Stuckey | 191 |
| Sullivan's Island | 1,930 |
| Summerton | 781 |
| Summerville | 52,145 |
| Summit | 458 |
| Sumter | 42,548 |
| Surfside Beach | 4,375 |
| Swansea | 771 |
| Sycamore | 136 |