| Zip Code | City | Population ↓ |
|---|---|---|
| 34135 | Bonita Springs | 48,252 |
| 33914 | Cape Coral | 45,540 |
| 33905 | Fort Myers | 41,381 |
| 33909 | Cape Coral | 40,231 |
| 33908 | Fort Myers | 37,423 |
| 33993 | Cape Coral | 35,580 |
| 33990 | Cape Coral | 34,713 |
| 33904 | Cape Coral | 33,599 |
| 33917 | North Fort Myers | 33,380 |
| 33928 | Estero | 31,926 |
| 33913 | Fort Myers | 31,538 |
| 33971 | Lehigh Acres | 30,790 |
| 33919 | Fort Myers | 30,412 |
| 33967 | Fort Myers | 28,341 |
| 33916 | Fort Myers | 27,943 |
| 33991 | Cape Coral | 27,725 |
| 33907 | Fort Myers | 25,033 |
| 33901 | Fort Myers | 24,481 |
| 33903 | North Fort Myers | 23,655 |
| 33976 | Lehigh Acres | 20,277 |
| 33974 | Lehigh Acres | 19,927 |
| 33912 | Fort Myers | 19,533 |
| 33972 | Lehigh Acres | 17,285 |
| 34134 | Bonita Springs | 16,475 |
| 33973 | Lehigh Acres | 14,392 |
| 33966 | Fort Myers | 12,513 |
| 33920 | Alva | 9,062 |
| 33931 | Fort Myers Beach | 8,350 |
| 33957 | Sanibel | 6,418 |
| 33965 | Fort Myers | 4,836 |
| 33922 | Bokeelia | 4,226 |
| 33956 | Saint James City | 3,405 |
| 33921 | Boca Grande | 391 |
| 33924 | Captiva | 109 |
The data shown reflect ZCTAs from the US Census. As of 2025, there are 34 ZCTAs in Lee County, Florida (US Census).