| Zip Code | City | Population ↓ |
|---|---|---|
| 14221 | Buffalo | 55,228 |
| 14075 | Hamburg | 44,610 |
| 14215 | Buffalo | 42,368 |
| 14150 | Tonawanda | 41,456 |
| 14224 | Buffalo | 40,745 |
| 14086 | Lancaster | 35,121 |
| 14225 | Buffalo | 34,063 |
| 14127 | Orchard Park | 30,652 |
| 14226 | Buffalo | 29,273 |
| 14207 | Buffalo | 25,699 |
| 14228 | Buffalo | 25,038 |
| 14043 | Depew | 24,936 |
| 14211 | Buffalo | 24,143 |
| 14216 | Buffalo | 24,009 |
| 14213 | Buffalo | 23,980 |
| 14220 | Buffalo | 23,926 |
| 14217 | Buffalo | 22,921 |
| 14223 | Buffalo | 22,482 |
| 14214 | Buffalo | 22,113 |
| 14206 | Buffalo | 21,726 |
| 14072 | Grand Island | 21,416 |
| 14227 | Buffalo | 21,329 |
| 14218 | Buffalo | 20,936 |
| 14051 | East Amherst | 19,747 |
| 14052 | East Aurora | 17,694 |
| 14222 | Buffalo | 15,744 |
| 14210 | Buffalo | 15,382 |
| 14212 | Buffalo | 13,295 |
| 14201 | Buffalo | 12,623 |
| 14208 | Buffalo | 11,820 |
| 14004 | Alden | 11,658 |
| 14219 | Buffalo | 10,854 |
| 14032 | Clarence Center | 10,572 |
| 14031 | Clarence | 9,685 |
| 14059 | Elma | 9,629 |
| 14006 | Angola | 9,402 |
| 14001 | Akron | 9,199 |
| 14209 | Buffalo | 8,677 |
| 14085 | Lake View | 8,298 |
| 14068 | Getzville | 7,990 |
| 14057 | Eden | 7,688 |
| 14204 | Buffalo | 7,666 |
| 14141 | Springville | 7,492 |
| 14047 | Derby | 6,147 |
| 14261 | Buffalo | 4,818 |
| 14080 | Holland | 4,215 |
| 14025 | Boston | 3,754 |
| 14202 | Buffalo | 3,664 |
| 14111 | North Collins | 3,150 |
| 14081 | Irving | 2,910 |
| 14034 | Collins | 2,513 |
| 14203 | Buffalo | 2,390 |
| 14170 | West Falls | 2,223 |
| 14139 | South Wales | 2,074 |
| 14030 | Chaffee | 2,045 |
| 14091 | Lawtons | 1,600 |
| 14102 | Marilla | 1,488 |
| 14033 | Colden | 1,460 |
| 14055 | East Concord | 1,455 |
| 14260 | Buffalo | 812 |
| 14069 | Glenwood | 630 |
| 14026 | Bowmansville | 506 |
| 14061 | Farnham | 93 |
| 14169 | Wales Center | 80 |
| 14134 | Sardinia | 72 |
| 14035 | Collins Center | 61 |
| 14112 | North Evans | 54 |
| 14027 | Brant | 34 |
The data shown reflect ZCTAs from the US Census. As of 2024, there are 68 ZCTAs in Erie County, New York (US Census).