| Zip Code | City | Population ↓ |
|---|---|---|
| 18702 | Wilkes Barre | 42,768 |
| 18201 | Hazleton | 31,519 |
| 18704 | Kingston | 30,973 |
| 18612 | Dallas | 18,033 |
| 18707 | Mountain Top | 16,366 |
| 18706 | Wilkes Barre | 16,224 |
| 18640 | Pittston | 16,014 |
| 18705 | Wilkes Barre | 15,387 |
| 18634 | Nanticoke | 13,623 |
| 18202 | Hazleton | 13,309 |
| 18643 | Pittston | 12,737 |
| 18222 | Drums | 9,958 |
| 18708 | Shavertown | 8,863 |
| 18651 | Plymouth | 8,704 |
| 18644 | Wyoming | 7,506 |
| 18641 | Pittston | 7,460 |
| 18224 | Freeland | 6,003 |
| 18655 | Shickshinny | 5,522 |
| 18621 | Hunlock Creek | 5,405 |
| 18661 | White Haven | 5,301 |
| 18249 | Sugarloaf | 4,022 |
| 18701 | Wilkes Barre | 3,710 |
| 18635 | Nescopeck | 3,567 |
| 18642 | Duryea | 3,545 |
| 18618 | Harveys Lake | 3,515 |
| 18660 | Wapwallopen | 3,335 |
| 18709 | Luzerne | 2,885 |
| 18656 | Sweet Valley | 2,224 |
| 18617 | Glen Lyon | 1,376 |
| 18219 | Conyngham | 1,052 |
| 18221 | Drifton | 441 |
| 18234 | Lattimer Mines | 409 |
| 18602 | Bear Creek | 365 |
| 18241 | Nuremberg | 335 |
| 18622 | Huntington Mills | 221 |
| 18246 | Rock Glen | 211 |
| 18256 | Weston | 179 |
| 18239 | Milnesville | 101 |
| 18223 | Ebervale | 75 |
| 18627 | Lehman | 0 |
| 18225 | Harleigh | 0 |
The data shown reflect ZCTAs from the US Census. As of 2024, there are 41 ZCTAs in Luzerne County, Pennsylvania (US Census).