| Zip Code | City | Population ↓ |
|---|---|---|
| 15370 | Waynesburg | 13,886 |
| 15320 | Carmichaels | 5,263 |
| 15344 | Jefferson | 1,657 |
| 15322 | Clarksville | 1,640 |
| 15338 | Greensboro | 1,565 |
| 15349 | Mount Morris | 1,509 |
| 15357 | Rices Landing | 1,460 |
| 15327 | Dilliner | 1,402 |
| 15351 | Nemacolin | 943 |
| 15315 | Bobtown | 792 |
| 15364 | Sycamore | 716 |
| 15352 | New Freeport | 712 |
| 15362 | Spraggs | 685 |
| 15380 | Wind Ridge | 655 |
| 15341 | Holbrook | 615 |
| 15337 | Graysville | 524 |
| 15346 | Mather | 487 |
| 15334 | Garards Fort | 336 |
| 15310 | Aleppo | 240 |
| 15325 | Crucible | 222 |
| 15316 | Brave | 222 |
| 15359 | Rogersville | 173 |
| 15353 | Nineveh | 62 |
The data shown reflect ZCTAs from the US Census. As of 2024, there are 23 ZCTAs in Greene County, Pennsylvania (US Census).