| County | Rank | Change (2020) ↓ | 2025 Pop. | 2020 Pop. |
|---|---|---|---|---|
| Jasper County | 1 | 25.76% | 36,660 | 29,150 |
| Horry County | 2 | 20.46% | 426,140 | 353,765 |
| Lancaster County | 3 | 19.27% | 115,197 | 96,588 |
| Berkeley County | 4 | 19.1% | 275,747 | 231,533 |
| Spartanburg County | 5 | 14.82% | 378,198 | 329,379 |
| Kershaw County | 6 | 12.84% | 74,015 | 65,590 |
| Edgefield County | 7 | 12.59% | 28,903 | 25,671 |
| Greenville County | 8 | 9.7% | 578,418 | 527,249 |
| Dorchester County | 9 | 9.48% | 177,399 | 162,043 |
| Beaufort County | 10 | 8.96% | 204,643 | 187,815 |
| McCormick County | 11 | 8.65% | 10,341 | 9,518 |
| Aiken County | 12 | 8.14% | 182,934 | 169,168 |
| York County | 13 | 7.93% | 306,558 | 284,028 |
| Lexington County | 14 | 7.91% | 318,374 | 295,047 |
| Anderson County | 15 | 7.7% | 219,924 | 204,195 |
| Georgetown County | 16 | 6.84% | 67,855 | 63,509 |
| Charleston County | 17 | 5.98% | 434,401 | 409,899 |
| Pickens County | 18 | 5.97% | 139,545 | 131,684 |
| Oconee County | 19 | 5.79% | 83,343 | 78,784 |
| Newberry County | 20 | 5.6% | 39,845 | 37,731 |
| Laurens County | 21 | 4.56% | 70,717 | 67,634 |
| Richland County | 22 | 4.02% | 432,362 | 415,671 |
| Chesterfield County | 23 | 3.13% | 44,611 | 43,256 |
| Saluda County | 24 | 3.04% | 19,401 | 18,828 |
| Cherokee County | 25 | 2.99% | 57,900 | 56,220 |
| Colleton County | 26 | 2.4% | 39,462 | 38,537 |
| Abbeville County | 27 | 1.48% | 24,626 | 24,266 |
| Chester County | 28 | 1.26% | 32,692 | 32,284 |
| Clarendon County | 29 | 1.03% | 31,158 | 30,841 |
| Florence County | 30 | 0.98% | 138,162 | 136,817 |
| Greenwood County | 31 | 0.78% | 69,934 | 69,390 |
| Calhoun County | 32 | 0.35% | 14,164 | 14,114 |
| Darlington County | 33 | -0.75% | 62,376 | 62,848 |
| Sumter County | 34 | -0.81% | 104,623 | 105,476 |
| Barnwell County | 35 | -0.91% | 20,399 | 20,586 |
| Marion County | 36 | -1.73% | 28,582 | 29,086 |
| Bamberg County | 37 | -1.79% | 13,022 | 13,260 |
| Orangeburg County | 38 | -2.02% | 82,258 | 83,954 |
| Hampton County | 39 | -2.27% | 18,094 | 18,515 |
| Dillon County | 40 | -2.39% | 27,600 | 28,277 |
| Fairfield County | 41 | -2.49% | 20,366 | 20,887 |
| Union County | 42 | -2.84% | 26,409 | 27,181 |
| Williamsburg County | 43 | -4.75% | 29,447 | 30,914 |
| Marlboro County | 44 | -5.25% | 25,100 | 26,490 |
| Lee County | 45 | -5.8% | 15,579 | 16,539 |
| Allendale County | 46 | -8.36% | 7,271 | 7,934 |
South Carolina's counties show varied growth patterns from 2020 to 2025. Jasper County leads with 25.76% annualized growth, followed by Horry County (20.46%) and Lancaster County (19.27%). The largest counties are Greenville County (578,418), Charleston County (434,401), and Richland County (432,362). Of the 46 counties in South Carolina, 32 are growing while 14 have experienced population decline. Overall, counties averaged 4.51% annualized growth, with total population growing by 8.23% annually.