| County | Rank | Change (2020) ↓ | 2025 Pop. | 2020 Pop. |
|---|---|---|---|---|
| Jasper County | 1 | 28.98% | 37,594 | 29,148 |
| Horry County | 2 | 21.09% | 428,408 | 353,779 |
| Lancaster County | 3 | 18.55% | 114,508 | 96,592 |
| Edgefield County | 4 | 17.95% | 30,281 | 25,673 |
| Berkeley County | 5 | 17.68% | 272,429 | 231,508 |
| Spartanburg County | 6 | 15.31% | 379,822 | 329,405 |
| Kershaw County | 7 | 11.67% | 73,251 | 65,596 |
| Dorchester County | 8 | 10.8% | 179,556 | 162,059 |
| Greenville County | 9 | 10.34% | 581,794 | 527,266 |
| Beaufort County | 10 | 8.92% | 204,589 | 187,829 |
| York County | 11 | 8.37% | 307,627 | 283,862 |
| Anderson County | 12 | 7.92% | 220,368 | 204,192 |
| Lexington County | 13 | 7.69% | 317,671 | 294,993 |
| Aiken County | 14 | 7.26% | 181,456 | 169,174 |
| McCormick County | 15 | 6.91% | 10,180 | 9,522 |
| Charleston County | 16 | 6.4% | 436,197 | 409,958 |
| Laurens County | 17 | 6.29% | 71,880 | 67,628 |
| Pickens County | 18 | 6.09% | 139,710 | 131,689 |
| Oconee County | 19 | 5.88% | 83,423 | 78,787 |
| Richland County | 20 | 4.9% | 436,066 | 415,697 |
| Newberry County | 21 | 4.64% | 39,490 | 37,738 |
| Georgetown County | 22 | 4.32% | 66,258 | 63,517 |
| Cherokee County | 23 | 4.22% | 58,597 | 56,226 |
| Chesterfield County | 24 | 3.7% | 44,856 | 43,254 |
| Saluda County | 25 | 3.68% | 19,604 | 18,908 |
| Colleton County | 26 | 2.44% | 39,478 | 38,538 |
| Abbeville County | 27 | 1.6% | 24,651 | 24,262 |
| Greenwood County | 28 | 1.59% | 70,500 | 69,395 |
| Florence County | 29 | 1.34% | 138,644 | 136,814 |
| Calhoun County | 30 | 1.25% | 14,290 | 14,113 |
| Chester County | 31 | 0.59% | 32,483 | 32,291 |
| Clarendon County | 32 | 0.32% | 30,941 | 30,841 |
| Barnwell County | 33 | -0.23% | 20,542 | 20,590 |
| Sumter County | 34 | -0.33% | 105,142 | 105,493 |
| Darlington County | 35 | -0.57% | 62,482 | 62,842 |
| Orangeburg County | 36 | -1.03% | 83,110 | 83,971 |
| Hampton County | 37 | -1.88% | 18,177 | 18,525 |
| Union County | 38 | -2.12% | 26,605 | 27,182 |
| Fairfield County | 39 | -2.52% | 20,346 | 20,872 |
| Dillon County | 40 | -2.96% | 27,442 | 28,280 |
| Marion County | 41 | -2.98% | 28,214 | 29,082 |
| Lee County | 42 | -3.37% | 15,989 | 16,546 |
| Bamberg County | 43 | -3.86% | 12,749 | 13,261 |
| Williamsburg County | 44 | -3.94% | 29,702 | 30,921 |
| Marlboro County | 45 | -4.8% | 25,224 | 26,496 |
| Allendale County | 46 | -5.39% | 7,506 | 7,934 |
South Carolina's counties show varied growth patterns from 2020 to 2025. Jasper County leads with 28.98% annualized growth, followed by Horry County (21.09%) and Lancaster County (18.55%). The largest counties are Greenville County (581,794), Charleston County (436,197), and Richland County (436,066). Of the 46 counties in South Carolina, 32 are growing while 14 have experienced population decline. Overall, counties averaged 4.84% annualized growth, with total population growing by 8.53% annually.
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