| County | Rank | Change (2020) ↓ | 2025 Pop. | 2020 Pop. |
|---|---|---|---|---|
| George County | 1 | 8.6% | 26,459 | 24,364 |
| Lafayette County | 2 | 7.2% | 59,941 | 55,913 |
| DeSoto County | 3 | 6.09% | 197,453 | 186,122 |
| Pearl River County | 4 | 5.97% | 59,568 | 56,211 |
| Madison County | 5 | 5.24% | 114,991 | 109,266 |
| Lamar County | 6 | 4.3% | 67,159 | 64,389 |
| Jackson County | 7 | 4.09% | 149,241 | 143,373 |
| Rankin County | 8 | 3.9% | 163,295 | 157,162 |
| Stone County | 9 | 3.55% | 18,986 | 18,335 |
| Union County | 10 | 2.75% | 28,588 | 27,822 |
| Prentiss County | 11 | 2.61% | 25,623 | 24,971 |
| Marshall County | 12 | 2.3% | 34,559 | 33,781 |
| Pontotoc County | 13 | 2.18% | 31,871 | 31,192 |
| Itawamba County | 14 | 1.98% | 24,337 | 23,865 |
| Webster County | 15 | 1.76% | 10,076 | 9,902 |
| Harrison County | 16 | 1.03% | 210,950 | 208,809 |
| Greene County | 17 | 0.98% | 13,671 | 13,538 |
| Hancock County | 18 | 0.74% | 46,463 | 46,123 |
| Wayne County | 19 | 0.68% | 19,943 | 19,808 |
| Forrest County | 20 | 0.62% | 78,672 | 78,189 |
| Leake County | 21 | 0.57% | 21,368 | 21,246 |
| Tate County | 22 | 0.51% | 28,265 | 28,121 |
| Walthall County | 23 | 0.5% | 13,941 | 13,871 |
| Simpson County | 24 | -0.01% | 25,899 | 25,901 |
| Marion County | 25 | -0.14% | 24,340 | 24,375 |
| Smith County | 26 | -0.42% | 14,133 | 14,193 |
| Lee County | 27 | -0.69% | 82,749 | 83,323 |
| Lincoln County | 28 | -0.72% | 34,578 | 34,828 |
| Franklin County | 29 | -0.74% | 7,608 | 7,665 |
| Adams County | 30 | -0.74% | 29,204 | 29,423 |
| Neshoba County | 31 | -0.8% | 28,759 | 28,991 |
| Yalobusha County | 32 | -0.85% | 12,332 | 12,438 |
| Panola County | 33 | -1.04% | 32,823 | 33,169 |
| Newton County | 34 | -1.15% | 21,011 | 21,256 |
| Montgomery County | 35 | -1.23% | 9,674 | 9,794 |
| Chickasaw County | 36 | -1.25% | 16,872 | 17,086 |
| Monroe County | 37 | -1.31% | 33,691 | 34,139 |
| Choctaw County | 38 | -1.67% | 8,074 | 8,211 |
| Oktibbeha County | 39 | -1.68% | 50,841 | 51,709 |
| Clarke County | 40 | -1.72% | 15,278 | 15,545 |
| Alcorn County | 41 | -1.79% | 34,111 | 34,733 |
| Jones County | 42 | -1.93% | 65,870 | 67,163 |
| Scott County | 43 | -2.05% | 27,401 | 27,974 |
| Covington County | 44 | -2.2% | 17,893 | 18,295 |
| Lawrence County | 45 | -2.32% | 11,701 | 11,979 |
| Copiah County | 46 | -2.48% | 27,568 | 28,270 |
| Winston County | 47 | -2.54% | 17,240 | 17,690 |
| Perry County | 48 | -2.66% | 11,149 | 11,454 |
| Jasper County | 49 | -2.84% | 15,885 | 16,350 |
| Tishomingo County | 50 | -3.01% | 18,279 | 18,846 |
| Grenada County | 51 | -3.01% | 20,927 | 21,577 |
| Clay County | 52 | -3.36% | 17,996 | 18,622 |
| Pike County | 53 | -3.44% | 38,808 | 40,192 |
| Tippah County | 54 | -3.48% | 20,985 | 21,742 |
| Lowndes County | 55 | -3.86% | 56,507 | 58,777 |
| Amite County | 56 | -3.87% | 12,208 | 12,700 |
| Yazoo County | 57 | -4.03% | 25,602 | 26,676 |
| Attala County | 58 | -4.5% | 17,017 | 17,818 |
| Jefferson Davis County | 59 | -4.61% | 10,749 | 11,269 |
| Lauderdale County | 60 | -4.65% | 69,297 | 72,675 |
| Noxubee County | 61 | -4.76% | 9,742 | 10,229 |
| Benton County | 62 | -6.03% | 7,202 | 7,664 |
| Kemper County | 63 | -6.12% | 8,412 | 8,960 |
| Issaquena County | 64 | -6.33% | 1,244 | 1,328 |
| Calhoun County | 65 | -6.48% | 12,363 | 13,219 |
| Warren County | 66 | -6.56% | 41,624 | 44,544 |
| Coahoma County | 67 | -6.89% | 19,761 | 21,224 |
| Hinds County | 68 | -7.61% | 209,500 | 226,765 |
| Jefferson County | 69 | -7.67% | 6,689 | 7,245 |
| Carroll County | 70 | -8.06% | 9,133 | 9,934 |
| Sunflower County | 71 | -8.22% | 23,730 | 25,856 |
| Leflore County | 72 | -8.45% | 25,806 | 28,188 |
| Washington County | 73 | -8.62% | 40,790 | 44,640 |
| Tunica County | 74 | -8.68% | 8,888 | 9,733 |
| Claiborne County | 75 | -8.75% | 8,301 | 9,097 |
| Wilkinson County | 76 | -8.89% | 7,768 | 8,526 |
| Bolivar County | 77 | -9.25% | 27,982 | 30,835 |
| Tallahatchie County | 78 | -10.05% | 11,377 | 12,648 |
| Humphreys County | 79 | -10.34% | 6,940 | 7,740 |
| Holmes County | 80 | -10.5% | 15,109 | 16,882 |
| Quitman County | 81 | -14.11% | 5,290 | 6,159 |
| Sharkey County | 82 | -18.24% | 3,084 | 3,772 |
Mississippi's counties show varied growth patterns from 2020 to 2025. George County leads with 8.6% annualized growth, followed by Lafayette County (7.2%) and DeSoto County (6.09%). The largest counties are Harrison County (210,950), Hinds County (209,500), and DeSoto County (197,453). Of the 82 counties in Mississippi, 23 are growing while 59 have experienced population decline. Overall, counties averaged -2.45% annualized growth, with total population growing by -0.58% annually.