11 zips
| Zip Code | City | Population ↓ |
|---|---|---|
| 29488 | Walterboro | 22,354 |
| 29435 | Cottageville | 4,462 |
| 29945 | Yemassee | 4,165 |
| 29475 | Ruffin | 2,324 |
| 29481 | Smoaks | 1,527 |
| 29474 | Round O | 1,487 |
| 29446 | Green Pond | 1,317 |
| 29929 | Islandton | 982 |
| 29082 | Lodge | 426 |
| 29452 | Jacksonboro | 246 |
| 29493 | Williams | 232 |
The data shown reflect ZCTAs from the US Census. As of 2024, there are 11 ZCTAs in Colleton County, South Carolina (US Census).