11 zips
| Zip Code | City | Population ↓ |
|---|---|---|
| 29488 | Walterboro | 22,367 |
| 29435 | Cottageville | 4,579 |
| 29945 | Yemassee | 3,652 |
| 29475 | Ruffin | 2,676 |
| 29481 | Smoaks | 1,742 |
| 29929 | Islandton | 1,301 |
| 29474 | Round O | 1,275 |
| 29446 | Green Pond | 1,257 |
| 29082 | Lodge | 377 |
| 29452 | Jacksonboro | 200 |
| 29493 | Williams | 162 |
The data shown reflect ZCTAs from the US Census. As of 2024, there are 11 ZCTAs in Colleton County, South Carolina (US Census).