| Zip Code | City | Population ↓ |
|---|---|---|
| 29501 | Florence | 48,673 |
| 29505 | Florence | 23,895 |
| 29506 | Florence | 20,777 |
| 29560 | Lake City | 12,277 |
| 29161 | Timmonsville | 9,688 |
| 29541 | Effingham | 9,326 |
| 29555 | Johnsonville | 5,972 |
| 29583 | Pamplico | 4,994 |
| 29591 | Scranton | 4,639 |
| 29530 | Coward | 2,641 |
| 29114 | Olanta | 1,786 |
The data shown reflect ZCTAs from the US Census. As of 2025, there are 11 ZCTAs in Florence County, South Carolina (US Census).