It is very unusual for presidents to die in office, but it has happened in the past. After the founding of the country, it did not take very long for a president to die in office. For example, William Henry Harrison, one of the very first presidents of the United States, was only in office for a month before he died. He contracted pneumonia shortly after he was elected to the office of President of the United States, and he passed away shortly thereafter. He served in the War of 1812 and was considered to be one of the top leaders of his time.
It has been a long time since the president died in office. The most recent president to die in office was John F Kennedy. He was elected president in 1960 and he served in the office from 1961 to 1963. Even though he was not in office for very long, he is still widely considered to be one of the greatest presidents of all time. He was assassinated in 1963 as he was riding in the back of a car with his wife. Eventually, his assassin, Lee Harvey Oswald was caught. Lee Harvey Oswald was killed by Jack Ruby before he could be executed. To this day, the assassination of John F Kennedy is still something that is actively discussed.
Yes, Franklin Delano Roosevelt also died in office. FDR is widely considered to be one of the greatest presidents in the history of this country. He is the only president to serve more than two terms in office, and he was in office for approximately 16 years. He also led the country to victory during WWII, and he is widely revered across the world, particularly among our allies. Unfortunately, he contracted polio relatively early in his life, and he was stuck in a wheelchair for the duration of it. He also passed away in 1945 of natural causes. When he died, Harry S Truman took over, and he was also elected president himself after he finished out FDR's final term.
There are several presidents who have been assassinated. In addition to John F. Kennedy, who is mentioned above, Abraham Lincoln was also assassinated in 1865. He led the Union Army to victory, and he guided the country through its most turbulent times. Unfortunately, there were still people who did not like that he restored the Union, and he was assassinated by John Wilkes Booth. Andrew Johnson took over as president after he passed away. Between Abraham Lincoln and John F. Kennedy, there were a few other presidents who were assassinated as well. For example, James Garfield, who served in the military, was assassinated near a train car. William McKinley, who served as president at the turn of the 20th century, was also assassinated.