19 cities
| City | Rank | County | 2025 Pop. ↓ |
|---|---|---|---|
| Wheeling | 1 | Ohio County | 25,682 |
| Weirton | 2 | Hancock County | 17,903 |
| Moundsville | 3 | Marshall County | 7,502 |
| Follansbee | 4 | Brooke County | 2,595 |
| Bethlehem | 5 | Brooke County | 2,521 |
| Wellsburg | 6 | Brooke County | 2,209 |
| Chester | 7 | Hancock County | 2,055 |
| McMechen | 8 | Marshall County | 1,561 |
| West Liberty | 9 | Ohio County | 1,431 |
| Glen Dale | 10 | Marshall County | 1,382 |
| Benwood | 11 | Marshall County | 1,153 |
| New Cumberland | 12 | Hancock County | 960 |
| Cameron | 13 | Marshall County | 796 |
| Bethany | 14 | Brooke County | 743 |
| Triadelphia | 15 | Ohio County | 637 |
| Beech Bottom | 16 | Brooke County | 504 |
| Clearview | 17 | Brooke County | 447 |
| Windsor Heights | 18 | Brooke County | 325 |
| Valley Grove | 19 | Ohio County | 258 |
Ohio County, Marshall County, Hancock County, and Brooke County are the counties generally considered part of Northern Panhandle West Virginia.