Karnes City is a city located in Karnes County Texas. It is also the county seat of Karnes County. With a 2020 population of 3,329, it is the 460th largest city in Texas and the 5912th largest city in the United States . Karnes City is currently declining at a rate of -0.80% annually but its population has increased by 9.43% since the most recent census, which recorded a population of 3,042 in 2010. Karnes City reached it's highest population of in . Spanning over 2 miles, Karnes City has a population density of 1,456 people per square mile.
The average household income in Karnes City is $93,601 with a poverty rate of 23.24%. The median rental costs in recent years comes to $829 per month, and the median house value is $76,500. The median age in Karnes City is 33.3 years, 33.1 years for males, and 33.3 years for females.