24 cities
| City | Rank | 2025 Pop. ↓ | 2020 Pop. | Annual Change | Density | Area (mi²) | Type |
|---|---|---|---|---|---|---|---|
| Metlakatla | 1 | 1,445 | 1,582 | 0.21% | 627 | 2 | CDP |
| Craig | 2 | 1,054 | 1,034 | 0.29% | 158 | 7 | City |
| Craig | 3 | 1,054 | 1,036 | 0.29% | 158 | 7 | City |
| Klawock | 4 | 716 | 721 | -0.14% | 1,051 | 1 | City |
| Klawock | 5 | 716 | 718 | -0.14% | 1,051 | 1 | City |
| Kake | 6 | 540 | 544 | -0.18% | 70 | 8 | City |
| Kake | 7 | 540 | 542 | -0.18% | 70 | 8 | City |
| Thorne Bay | 8 | 473 | 477 | -0.21% | 18 | 27 | City |
| Thorne Bay | 9 | 473 | 475 | -0.21% | 18 | 27 | City |
| Hydaburg | 10 | 378 | 381 | -0.26% | 1,295 | 0 | City |
| Hydaburg | 11 | 378 | 380 | -0.26% | 1,295 | 0 | City |
| Hollis | 12 | 144 | 198 | 1.41% | 2 | 65 | CDP |
| Coffman Cove | 13 | 127 | 129 | -0.78% | 12 | 11 | City |
| Coffman Cove | 14 | 127 | 129 | -0.78% | 12 | 11 | City |
| Naukati Bay | 15 | 122 | 110 | 0.83% | 25 | 5 | CDP |
| Whale Pass | 16 | 87 | 87 | 0% | 4 | 20 | City |
| Whale Pass | 17 | 87 | 87 | 0% | 4 | 20 | City |
| Port Alexander | 18 | 74 | 74 | 0% | 21 | 4 | City |
| Port Alexander | 19 | 74 | 74 | 0% | 21 | 4 | City |
| Kasaan | 20 | 29 | 29 | 0% | 5 | 6 | City |
| Kasaan | 21 | 29 | 29 | 0% | 5 | 6 | City |
| Edna Bay | 22 | 26 | 26 | 0% | 1 | 21 | City |
| Edna Bay | 23 | 26 | 26 | 0% | 1 | 21 | City |
| Hyder | 24 | 20 | 12 | 5.26% | 1 | 17 | CDP |
Metlakatla is the largest city in Prince of Wales-Hyder Census Area, with a population of 1,445.
Hyder is the smallest city in Prince of Wales-Hyder Census Area, with a population of 20.
There are 24 cities in Prince of Wales-Hyder Census Area, Alaska.