| City | Rank | 2026 Pop. ↓ | 2020 Pop. | Annual Change | Density (/mi²) | Area (mi²) | Type |
|---|---|---|---|---|---|---|---|
| Santa Rosa | 1 | 2,792 | 2,851 | -0.36% | 559 | 5 | City |
| Vaughn | 2 | 270 | 280 | -0.74% | 48 | 6 | Town |
Santa Rosa is the largest city in Guadalupe County, with a population of 2,792.
Vaughn is the smallest city in Guadalupe County, with a population of 270.
There are 2 cities in Guadalupe County, New Mexico.