| City | Rank | 2026 Pop. ↓ | 2020 Pop. | Annual Change | Density (/mi²) | Area (mi²) | Type |
|---|---|---|---|---|---|---|---|
| Henderson | 1 | 14,986 | 15,139 | -0.18% | 1,738 | 9 | City |
| Kittrell | 2 | 126 | 128 | -0.79% | 606 | 0 | Town |
| Middleburg | 3 | 98 | 98 | 0% | 125 | 1 | Town |
Henderson is the largest city in Vance County, with a population of 14,986.
Middleburg is the smallest city in Vance County, with a population of 98.
There are 3 cities in Vance County, North Carolina.