4 cities
| City | Rank | 2025 Pop. ↓ | 2020 Pop. | Change | Density | Area (mi²) | Type |
|---|---|---|---|---|---|---|---|
| Henderson | 1 | 14,723 | 15,058 | -0.45% | 1,707 | 8.62 | City |
| South Henderson | 2 | 1,180 | 1,055 | -0.25% | 655 | 1.80 | CDP |
| Kittrell | 3 | 126 | 128 | 0% | 606 | 0.21 | Town |
| Middleburg | 4 | 103 | 103 | 0% | 131 | 0.79 | Town |
Henderson is the largest city in Vance County, with a population of 14,723.
Middleburg is the smallest city in Vance County.
There are 4 cities in Vance County, North Carolina.