Cuenca's 2021 population is now estimated at 427,315. In 1950, the population of Cuenca was 39,418. Cuenca has grown by 8,943 since 2015, which represents a 2.14% annual change. These population estimates and projections come from the latest revision of the UN World Urbanization Prospects. These estimates represent the Urban agglomeration of Cuenca, which typically includes Cuenca's population in addition to adjacent suburban areas.