6 cities
| City | Rank | 2025 Pop. ↓ | 2020 Pop. | Change | Density | Area (mi²) | Type |
|---|---|---|---|---|---|---|---|
| Santa Rosa | 1 | 2,715 | 2,850 | -0.98% | 543 | 5 | City |
| Tecolotito | 2 | 562 | 549 | 4.07% | 782 | 0.72 | CDP |
| Puerto Luna | 3 | 453 | 226 | 4.62% | 32 | 14.19 | CDP |
| Vaughn | 4 | 258 | 280 | -1.53% | 46 | 5.60 | Town |
| Anton Chico | 5 | 188 | 120 | 0% | 105 | 1.79 | CDP |
| Pastura | 6 | 4 | 3 | 0% | 12 | 0.35 | CDP |
Santa Rosa is the largest city in Guadalupe County, with a population of 2,715.
Pastura is the smallest city in Guadalupe County.
There are 6 cities in Guadalupe County, New Mexico.