2 cities
| City | Rank | 2026 Pop. ↓ | 2020 Pop. | Annual Change | Density | Area (mi²) | Type |
|---|---|---|---|---|---|---|---|
| Santa Rosa | 1 | 2,810 | 2,852 | -0.25% | 562 | 5 | City |
| Vaughn | 2 | 273 | 279 | -0.36% | 49 | 6 | Town |
Santa Rosa is the largest city in Guadalupe County, with a population of 2,810.
Vaughn is the smallest city in Guadalupe County, with a population of 273.
There are 2 cities in Guadalupe County, New Mexico.