| City | Rank | 2026 Pop. ↓ | 2020 Pop. | Annual Change | Density (/mi²) | Area (mi²) | Type |
|---|---|---|---|---|---|---|---|
| Dover-Foxcroft | 1 | 4,422 | 4,423 | -0.92% | 65 | 68 | Town |
| Milo | 2 | 2,340 | 2,252 | -0.43% | 71 | 33 | Town |
| Greenville | 3 | 1,807 | 1,440 | 3.67% | 43 | 42 | Town |
| Sangerville | 4 | 1,325 | 1,309 | -0.82% | 34 | 38 | Town |
| Guilford | 5 | 1,272 | 1,266 | -1.01% | 36 | 35 | Town |
| Brownville | 6 | 1,145 | 1,137 | -0.69% | 26 | 44 | Town |
| Parkman | 7 | 752 | 746 | -0.92% | 17 | 45 | Town |
| Sebec | 8 | 670 | 666 | -0.89% | 18 | 37 | Town |
| Monson | 9 | 645 | 608 | 0.47% | 14 | 47 | Town |
| Abbot | 10 | 632 | 653 | -0.94% | 18 | 35 | Town |
| Shirley | 11 | 274 | 253 | -0.36% | 5.0 | 53 | Town |
| Medford | 12 | 232 | 231 | -1.28% | 5.0 | 42 | Town |
| Wellington | 13 | 231 | 226 | -0.43% | 6.0 | 40 | Town |
| Lake View | 14 | 151 | 150 | -0.66% | 4.0 | 41 | Plantation |
| Bowerbank | 15 | 135 | 137 | -1.46% | 3.0 | 42 | Town |
| Willimantic | 16 | 135 | 135 | -0.74% | 3.0 | 43 | Town |
| Beaver Cove | 17 | 133 | 132 | -0.75% | 4.0 | 32 | Town |
| Kingsbury | 18 | 29 | 30 | -3.33% | 1.0 | 44 | Plantation |
Dover-Foxcroft is the largest city in Piscataquis County, with a population of 4,422.
Kingsbury is the smallest city in Piscataquis County, with a population of 29.
There are 18 cities in Piscataquis County, Maine.