| City | Rank | 2026 Pop. ↓ | 2020 Pop. | Annual Change | Density (/mi²) | Area (mi²) | Type |
|---|---|---|---|---|---|---|---|
| Hartsville | 1 | 12,758 | 11,646 | 1.07% | 112 | 114 | Township |
| Lafayette | 2 | 6,107 | 5,590 | 1.45% | 1,153 | 5 | City |
| Red Boiling Springs | 3 | 1,203 | 1,202 | 0.17% | 687 | 2 | City |
Hartsville is the largest city in Macon County, with a population of 12,758.
Red Boiling Springs is the smallest city in Macon County, with a population of 1,203.
There are 3 cities in Macon County, Tennessee.