2 cities
| City | Rank | 2025 Pop. ↓ | 2020 Pop. | Annual Change | Density | Area (mi²) | Type |
|---|---|---|---|---|---|---|---|
| Wytheville | 1 | 8,132 | 8,270 | -0.34% | 561 | 14 | Town |
| Rural Retreat | 2 | 1,526 | 1,543 | -0.26% | 670 | 2 | Town |
Wytheville is the largest city in Wythe County, with a population of 8,132.
Rural Retreat is the smallest city in Wythe County, with a population of 1,526.
There are 2 cities in Wythe County, Virginia.