13 cities
| City | Rank | 2025 Pop. ↓ | 2020 Pop. | Annual Change | Density | Area (mi²) | Type |
|---|---|---|---|---|---|---|---|
| New Martinsville | 1 | 4,996 | 5,205 | -0.83% | 1,869 | 3 | City |
| New Martinsville | 2 | 4,996 | 5,204 | -0.83% | 1,869 | 3 | City |
| Paden City | 3 | 2,351 | 2,544 | -1.55% | 2,779 | 1 | City |
| Paden City | 4 | 2,351 | 2,533 | -1.55% | 2,779 | 1 | City |
| Pine Grove | 5 | 335 | 362 | -1.47% | 952 | 0 | Town |
| Pine Grove | 6 | 335 | 360 | -1.47% | 952 | 0 | Town |
| Hundred | 7 | 238 | 258 | -1.65% | 474 | 1 | Town |
| Hundred | 8 | 238 | 257 | -1.65% | 474 | 1 | Town |
| Smithfield | 9 | 96 | 105 | -2.04% | 329 | 0 | Town |
| Smithfield | 10 | 96 | 105 | -2.04% | 329 | 0 | Town |
| Jacksonburg | 11 | 95 | 79 | -5% | 64 | 1 | CDP |
| Littleton | 12 | 70 | 184 | -11.39% | 107 | 1 | CDP |
| Reader | 13 | 58 | 290 | -28.4% | 62 | 1 | CDP |
New Martinsville is the largest city in Wetzel County, with a population of 4,996.
Reader is the smallest city in Wetzel County, with a population of 58.
There are 13 cities in Wetzel County, West Virginia.