| Zip Code | City | Population ↓ |
|---|---|---|
| 45662 | Portsmouth | 27,304 |
| 45694 | Wheelersburg | 12,530 |
| 45648 | Lucasville | 11,212 |
| 45663 | West Portsmouth | 6,389 |
| 45653 | Minford | 3,745 |
| 45652 | McDermott | 3,477 |
| 45629 | Franklin Furnace | 3,074 |
| 45682 | South Webster | 1,976 |
| 45657 | Otway | 1,482 |
| 45699 | Lucasville | 1,246 |
| 45630 | Friendship | 462 |
| 45671 | Rarden | 444 |
| 45636 | Haverhill | 223 |
| 45677 | Scioto Furnace | 51 |
The data shown reflect ZCTAs from the US Census. As of 2024, there are 14 ZCTAs in Scioto County, Ohio (US Census).