The estimated rate of heart defects was set by the March of Dimes at 7.9/1000 for every country. This rate is expected to diversify as more data becomes available and more countries implement preventative measures.
Birth defects are also known in the medical field as congenital disorders, congenital abnormalities, or congenital malformations.
More than 7,000 possible birth defects have been identified, varying in severity from inconsequential to fatal.
The most common severe congenital disorders are heart/cardiovascular defects, neural tube defects, hemoglobin disorders (thalassemia and sickle-cell disease), Down syndrome, and Glucose-6-phosphate dehydrogenase (G6PD) deficiency.
The likelihood of birth defects is influenced by multiple factors, including genetics, socioeconomics and demographics, and environmental factors such as maternal illnesses and drug use.
Many congenital disorders are preventable via methods such as vaccinations, proper nutrition, and adequate folic acid or iodine intake during pregnancy.
Congenital disorders vary in severity. The frequency of the most severe disorders is directly related to a country’s overall development. According to March of Dimes, 94% of the births with serious birth defects occur in low- and middle-income countries, as do 95% of the deaths from such defects.
According to the World Health Organization, an estimated 240,000 newborns die worldwide within 28 days of birth every year due to congenital disorders. Congenital disorders cause a further 170,000 deaths of children between the ages of 1 month and 5 years.
Besides poverty, reasons for the increased rates of severe birth defects in poor countries include (1) reduced availability and quality of maternal and child health services; (2) increased frequency of consanguineous marriages; (3) higher percentage of older mothers; and (4) higher concentration of a particular gene combination that boosts the chance of surviving malaria (hence its prevalence), but also increases the likelihood of sickle cell and thalassemia disorders.