| City | Rank | 2026 Pop. ↓ | 2020 Pop. | Annual Change | Density (/mi²) | Area (mi²) | Type |
|---|---|---|---|---|---|---|---|
| Redfield | 1 | 2,093 | 2,208 | -0.99% | 1,086 | 2 | City |
| Tulare | 2 | 204 | 210 | -0.97% | 797 | 0 | Town |
| Doland | 3 | 194 | 201 | -1.02% | 330 | 1 | City |
| Mellette | 4 | 192 | 199 | -1.03% | 750 | 0 | City |
| Conde | 5 | 138 | 143 | -0.72% | 245 | 1 | City |
| Northville | 6 | 134 | 138 | -0.74% | 356 | 0 | Town |
| Frankfort | 7 | 131 | 135 | -0.76% | 166 | 1 | City |
| Ashton | 8 | 103 | 106 | -0.96% | 235 | 0 | City |
| Brentford | 9 | 85 | 87 | -1.16% | 521 | 0 | Town |
| Turton | 10 | 53 | 56 | -1.85% | 144 | 0 | Town |
Redfield is the largest city in Spink County, with a population of 2,093.
Turton is the smallest city in Spink County, with a population of 53.
There are 10 cities in Spink County, South Dakota.