| City | Rank | 2026 Pop. ↓ | 2020 Pop. | Annual Change | Density (/mi²) | Area (mi²) | Type |
|---|---|---|---|---|---|---|---|
| Miller | 1 | 1,306 | 1,344 | -0.53% | 1,319 | 1 | City |
| St. Lawrence | 2 | 161 | 165 | -0.62% | 469 | 0 | Town |
| Ree Heights | 3 | 59 | 59 | 0% | 199 | 0 | Town |
| Orient | 4 | 54 | 51 | 0% | 184 | 0 | Town |
Miller is the largest city in Hand County, with a population of 1,306.
Orient is the smallest city in Hand County, with a population of 54.
There are 4 cities in Hand County, South Dakota.