4 cities
| City | Rank | 2026 Pop. ↓ | 2020 Pop. | Annual Change | Density | Area (mi²) | Type |
|---|---|---|---|---|---|---|---|
| Miller | 1 | 1,288 | 1,344 | -0.69% | 1,301 | 1 | City |
| St. Lawrence | 2 | 159 | 165 | -0.63% | 464 | 0 | Town |
| Ree Heights | 3 | 55 | 55 | 0% | 186 | 0 | Town |
| Orient | 4 | 51 | 51 | 0% | 173 | 0 | Town |
Miller is the largest city in Hand County, with a population of 1,288.
Orient is the smallest city in Hand County, with a population of 51.
There are 4 cities in Hand County, South Dakota.