3 cities
| City | Rank | 2026 Pop. ↓ | 2020 Pop. | Annual Change | Density | Area (mi²) | Type |
|---|---|---|---|---|---|---|---|
| Chamberlain | 1 | 2,443 | 2,472 | -0.2% | 545 | 4 | City |
| Kimball | 2 | 575 | 568 | 0.17% | 167 | 3 | City |
| Pukwana | 3 | 237 | 233 | 0.42% | 309 | 1 | Town |
Chamberlain is the largest city in Brule County, with a population of 2,443.
Pukwana is the smallest city in Brule County, with a population of 237.
There are 3 cities in Brule County, South Dakota.