| City | Rank | 2026 Pop. ↓ | 2020 Pop. | Annual Change | Density (/mi²) | Area (mi²) | Type |
|---|---|---|---|---|---|---|---|
| Chamberlain | 1 | 2,451 | 2,475 | -0.08% | 547 | 4 | City |
| Kimball | 2 | 580 | 567 | 0.35% | 169 | 3 | City |
| Pukwana | 3 | 239 | 232 | 0.42% | 312 | 1 | Town |
Chamberlain is the largest city in Brule County, with a population of 2,451.
Pukwana is the smallest city in Brule County, with a population of 239.
There are 3 cities in Brule County, South Dakota.