12 cities
| City | Rank | 2025 Pop. ↓ | 2020 Pop. | Change | Density | Area (mi²) | Type |
|---|---|---|---|---|---|---|---|
| Redfield | 1 | 2,077 | 2,211 | -1.28% | 1,077 | 1.93 | City |
| Glendale Colony | 2 | 254 | 190 | 7.17% | 530 | 0.48 | CDP |
| Tulare | 3 | 202 | 209 | -0.49% | 789 | 0.26 | Town |
| Mellette | 4 | 193 | 198 | -0.52% | 754 | 0.26 | City |
| Doland | 5 | 185 | 195 | -1.07% | 315 | 0.59 | City |
| Conde | 6 | 137 | 144 | -0.73% | 243 | 0.56 | City |
| Northville | 7 | 134 | 139 | -0.74% | 356 | 0.38 | Town |
| Frankfort | 8 | 127 | 134 | -0.78% | 161 | 0.79 | City |
| Ashton | 9 | 104 | 108 | -0.95% | 237 | 0.44 | City |
| Brentford | 10 | 82 | 86 | -1.21% | 503 | 0.16 | Town |
| Spink Colony | 11 | 59 | 0 | 7.27% | 166 | 0.35 | CDP |
| Turton | 12 | 53 | 55 | 0% | 144 | 0.37 | Town |
Redfield is the largest city in Spink County, with a population of 2,077.
Turton is the smallest city in Spink County.
There are 12 cities in Spink County, South Dakota.