44 cities
| City | Rank | 2025 Pop. ↓ | 2020 Pop. | Annual Change | Density | Area (mi²) | Type |
|---|---|---|---|---|---|---|---|
| Redfield | 1 | 2,075 | 2,203 | -1.24% | 1,076 | 2 | City |
| Redfield | 2 | 379 | 387 | -0.26% | 11 | 35 | Township |
| Lincoln | 3 | 329 | 340 | -1.2% | 9 | 35 | Township |
| Capitola | 4 | 261 | 269 | -1.14% | 7 | 36 | Township |
| Tulare | 5 | 202 | 211 | -0.98% | 789 | 0 | Town |
| Doland | 6 | 193 | 202 | -1.03% | 328 | 1 | City |
| Mellette | 7 | 191 | 198 | -1.04% | 746 | 0 | City |
| Northville | 8 | 150 | 156 | -0.66% | 2 | 99 | Township |
| Conde | 9 | 138 | 143 | -0.72% | 245 | 1 | City |
| Northville | 10 | 132 | 139 | -1.49% | 351 | 0 | Town |
| Frankfort | 11 | 129 | 136 | -1.53% | 164 | 1 | City |
| Mellette | 12 | 109 | 116 | -1.8% | 1 | 75 | Township |
| Prairie Center | 13 | 108 | 117 | -1.82% | 3 | 36 | Township |
| Ashton | 14 | 103 | 110 | -1.9% | 235 | 0 | City |
| Lake | 15 | 96 | 101 | -1.03% | 3 | 33 | Township |
| Brentford | 16 | 85 | 87 | -1.16% | 521 | 0 | Town |
| Belle Plaine | 17 | 80 | 82 | 1.27% | 2 | 36 | Township |
| Crandon | 18 | 79 | 79 | 2.6% | 2 | 36 | Township |
| Belmont | 19 | 66 | 67 | 1.54% | 2 | 36 | Township |
| Three Rivers | 20 | 64 | 65 | 1.59% | 2 | 36 | Township |
| La Prairie | 21 | 58 | 57 | 3.57% | 1 | 50 | Township |
| Exline | 22 | 57 | 62 | -1.72% | 2 | 37 | Township |
| Lodi | 23 | 55 | 56 | 1.85% | 2 | 37 | Township |
| Antelope | 24 | 54 | 54 | 1.89% | 2 | 36 | Township |
| Athol | 25 | 52 | 55 | -1.89% | 1 | 48 | Township |
| Groveland | 26 | 52 | 56 | -1.89% | 1 | 36 | Township |
| Harmony | 27 | 52 | 54 | -1.89% | 1 | 36 | Township |
| Turton | 28 | 51 | 54 | -1.92% | 139 | 0 | Town |
| Garfield | 29 | 47 | 51 | -2.08% | 1 | 36 | Township |
| Union | 30 | 46 | 47 | 0% | 1 | 36 | Township |
| Tulare | 31 | 45 | 47 | -2.17% | 1 | 34 | Township |
| Frankfort | 32 | 43 | 45 | -2.27% | 1 | 35 | Township |
| Tetonka | 33 | 43 | 43 | 2.38% | 1 | 59 | Township |
| Cornwall | 34 | 38 | 38 | 0% | 1 | 36 | Township |
| Great Bend | 35 | 38 | 40 | 0% | 1 | 36 | Township |
| Olean | 36 | 38 | 42 | -2.56% | 1 | 36 | Township |
| Clifton | 37 | 36 | 38 | 0% | 1 | 48 | Township |
| Beotia | 38 | 28 | 31 | -3.45% | 1 | 36 | Township |
| Turton | 39 | 24 | 27 | -4% | 1 | 36 | Township |
| Conde | 40 | 23 | 26 | -4.17% | 1 | 35 | Township |
| Benton | 41 | 22 | 23 | 0% | 1 | 36 | Township |
| Richfield | 42 | 22 | 23 | 0% | 1 | 36 | Township |
| Spring | 43 | 21 | 22 | 0% | 1 | 36 | Township |
| Sumner | 44 | 13 | 14 | 0% | 0.00 | 36 | Township |
Redfield is the largest city in Spink County, with a population of 2,075.
Sumner is the smallest city in Spink County, with a population of 13.
There are 44 cities in Spink County, South Dakota.