24 cities
| City | Rank | 2026 Pop. ↓ | 2020 Pop. | Annual Change | Density | Area (mi²) | Type |
|---|---|---|---|---|---|---|---|
| Chamberlain | 1 | 2,443 | 2,472 | -0.2% | 545 | 4 | City |
| Kimball | 2 | 575 | 568 | 0.17% | 167 | 3 | City |
| Wilbur | 3 | 264 | 250 | 1.54% | 7 | 36 | Township |
| Pukwana | 4 | 237 | 233 | 0.42% | 309 | 1 | Town |
| Chamberlain | 5 | 226 | 237 | -2.16% | 11 | 20 | Township |
| Torrey Lake | 6 | 213 | 222 | -1.84% | 6 | 36 | Township |
| Brule | 7 | 162 | 163 | -0.61% | 4 | 42 | Township |
| Pukwana | 8 | 143 | 144 | -0.69% | 4 | 35 | Township |
| West Point | 9 | 105 | 107 | -1.87% | 2 | 47 | Township |
| Ola | 10 | 95 | 99 | -2.06% | 3 | 36 | Township |
| Cleveland | 11 | 87 | 88 | -1.14% | 2 | 37 | Township |
| Red Lake | 12 | 79 | 78 | -1.25% | 3 | 30 | Township |
| Union | 13 | 72 | 73 | -1.37% | 2 | 36 | Township |
| Waldro | 14 | 71 | 72 | -1.39% | 2 | 37 | Township |
| Richland | 15 | 52 | 53 | -1.89% | 1 | 36 | Township |
| Kimball | 16 | 50 | 51 | -1.96% | 2 | 32 | Township |
| Smith | 17 | 47 | 46 | 0% | 1 | 36 | Township |
| America | 18 | 46 | 45 | 0% | 1 | 42 | Township |
| Eagle | 19 | 42 | 41 | 0% | 1 | 35 | Township |
| Pleasant Grove | 20 | 40 | 37 | 2.56% | 1 | 35 | Township |
| Lyon | 21 | 36 | 33 | 2.86% | 1 | 35 | Township |
| Highland | 22 | 32 | 31 | 0% | 1 | 36 | Township |
| Plainfield | 23 | 30 | 33 | -3.23% | 1 | 35 | Township |
| Plummer | 24 | 15 | 15 | 0% | 0.00 | 36 | Township |
Chamberlain is the largest city in Brule County, with a population of 2,443.
Plummer is the smallest city in Brule County, with a population of 15.
There are 24 cities in Brule County, South Dakota.