3 cities
| City | Rank | 2025 Pop. ↓ | 2020 Pop. | Change | Density | Area (mi²) | Type |
|---|---|---|---|---|---|---|---|
| Chamberlain | 1 | 2,502 | 2,474 | 0.24% | 559 | 4.48 | City |
| Kimball | 2 | 588 | 570 | 0.69% | 171 | 3.44 | City |
| Pukwana | 3 | 241 | 233 | 0.84% | 314 | 0.77 | Town |
Chamberlain is the largest city in Brule County, with a population of 2,502.
Pukwana is the smallest city in Brule County.
There are 3 cities in Brule County, South Dakota.