South Illinois Cities

City	Rank	County	2025 Pop. ↓
Carbondale	1	Jackson County	22,213
Marion	2	Williamson County	17,068
Mount Vernon	3	Jefferson County	14,060
Herrin	4	Williamson County	12,230
Harrisburg	5	Saline County	7,858
West Frankfort	6	Franklin County	7,099
Murphysboro	7	Jackson County	7,035
Benton	8	Franklin County	6,547
Carterville	9	Williamson County	5,812
Metropolis	10	Massac County	5,731
Du Quoin	11	Perry County	5,561
Pinckneyville	12	Perry County	4,937
Fairfield	13	Wayne County	4,765
Anna	14	Union County	4,135
Eldorado	15	Saline County	3,545
Johnston City	16	Williamson County	3,291
Christopher	17	Franklin County	2,605
McLeansboro	18	Franklin County	2,578
Sesser	19	Franklin County	1,871
Cambria	20	Williamson County	1,853
Ina	21	Jefferson County	1,647
Jonesboro	22	Union County	1,642
Carrier Mills	23	Saline County	1,584
Crainville	24	Jackson County	1,505
Cairo	25	Alexander County	1,474
Zeigler	26	Franklin County	1,461
De Soto	27	Jackson County	1,408
Vienna	28	Johnson County	1,349
Goreville	29	Johnson County	1,051
Royalton	30	Franklin County	1,037
Cobden	31	Union County	1,032
Wayne City	32	Wayne County	989
Energy	33	Williamson County	953
Rosiclare	34	Hardin County	946
Harrison	35	Jackson County	945
Elkville	36	Jackson County	833
Galatia	37	Saline County	778
Hurst	38	Williamson County	748
Brookport	39	Massac County	683
Dongola	40	Union County	641
West City	41	Franklin County	636
Cisne	42	Wayne County	620
Golconda	43	Pope County	619
Woodlawn	44	Jefferson County	603
Bluford	45	Jefferson County	599
Mounds	46	Pulaski County	596
Pittsburg	47	Williamson County	559
Willisville	48	Perry County	554
Ava	49	Jackson County	546
Makanda	50	Jackson County	539
Valier	51	Franklin County	535
Tamaroa	52	Perry County	523
Creal Springs	53	Williamson County	496
North City	54	Franklin County	496
Dahlgren	55	Hamilton County	490
Thompsonville	56	Franklin County	477
Grand Tower	57	Jackson County	474
Mound City	58	Pulaski County	471
Ullin	59	Pulaski County	455
Dix	60	Jefferson County	453
Waltonville	61	Jefferson County	398
Karnak	62	Pulaski County	397
Buckner	63	Franklin County	395
Olive Branch	64	Alexander County	376
Whiteash	65	Williamson County	369
Dowell	66	Jackson County	367
Crab Orchard	67	Williamson County	363
Bonnie	68	Jefferson County	362
Tamms	69	Alexander County	361
Cutler	70	Perry County	352
Jeffersonville	71	Wayne County	348
Joppa	72	Massac County	328
Blairsville	73	Jackson County	322
Orient	74	Franklin County	319
Hanaford	75	Franklin County	313
Campbell Hill	76	Jackson County	307
Alto Pass	77	Union County	303
Belle Rive	78	Jefferson County	298
Ewing	79	Franklin County	294
Raleigh	80	Saline County	275
Freeman Spur	81	Williamson County	270
Opdyke	82	Jefferson County	264
Olmsted	83	Pulaski County	262
East Cape Girardeau	84	Alexander County	244
Bush	85	Jackson County	236
Vergennes	86	Jackson County	236
Elizabethtown	87	Hardin County	221
Cave-In-Rock	88	Hardin County	219
Cypress	89	Johnson County	219
Stonefort	90	Saline County	218
McClure	91	Alexander County	217
Buncombe	92	Johnson County	207
Nason	93	Jefferson County	195
Broughton	94	Hamilton County	178
Unity	95	Alexander County	177
Spillertown	96	Williamson County	176
Thebes	97	Alexander County	176
Colp	98	Williamson County	174
Gorham	99	Jackson County	171
Sims	100	Wayne County	168
New Minden	101	Perry County	162
St. Johns	102	Jackson County	155
New Burnside	103	Johnson County	152
New Grand Chain	104	Massac County	143
Pulaski	105	Pulaski County	140
Eddyville	106	Pope County	96
Mount Erie	107	Wayne County	94
Belknap	108	Johnson County	86
Johnsonville	109	Wayne County	70
Mulkeytown	110	Franklin County	70
Golden Gate	111	Wayne County	61
Muddy	112	Saline County	56
Mill Creek	113	Pulaski County	55
Keenes	114	Wayne County	49
Belle Prairie City	115	Hamilton County	45
Simpson	116	Johnson County	44
Macedonia	117	Hamilton County	29

City

Rank

County

2025 Pop. ↓

22,213

17,068