South Illinois Cities

City	Rank	County	2026 Pop. ↓
Carbondale	1	Jackson County	22,203
Marion	2	Williamson County	17,116
Mount Vernon	3	Jefferson County	13,958
Herrin	4	Williamson County	12,207
Harrisburg	5	Saline County	7,779
West Frankfort	6	Franklin County	7,067
Murphysboro	7	Jackson County	7,027
Benton	8	Franklin County	6,517
Carterville	9	Williamson County	5,803
Metropolis	10	Massac County	5,687
Du Quoin	11	Perry County	5,511
Pinckneyville	12	Perry County	4,912
Fairfield	13	Wayne County	4,741
Anna	14	Union County	4,106
Eldorado	15	Saline County	3,508
Johnston City	16	Williamson County	3,274
Christopher	17	Franklin County	2,590
McLeansboro	18	Franklin County	2,564
Cambria	19	Williamson County	1,914
Sesser	20	Franklin County	1,867
Ina	21	Jefferson County	1,647
Jonesboro	22	Union County	1,630
Carrier Mills	23	Saline County	1,569
Crainville	24	Jackson County	1,517
Zeigler	25	Franklin County	1,457
Cairo	26	Alexander County	1,426
De Soto	27	Jackson County	1,408
Vienna	28	Johnson County	1,349
Goreville	29	Johnson County	1,049
Royalton	30	Franklin County	1,032
Cobden	31	Union County	1,024
Wayne City	32	Wayne County	986
Energy	33	Williamson County	950
Harrison	34	Jackson County	943
Rosiclare	35	Hardin County	938
Elkville	36	Jackson County	833
Galatia	37	Saline County	770
Hurst	38	Williamson County	746
Brookport	39	Massac County	676
Dongola	40	Union County	637
West City	41	Franklin County	633
Cisne	42	Wayne County	619
Golconda	43	Pope County	616
Woodlawn	44	Jefferson County	600
Bluford	45	Jefferson County	594
Mounds	46	Pulaski County	585
Pittsburg	47	Williamson County	557
Willisville	48	Perry County	550
Ava	49	Jackson County	546
Makanda	50	Jackson County	539
Valier	51	Franklin County	531
Tamaroa	52	Perry County	519
Creal Springs	53	Williamson County	494
North City	54	Franklin County	493
Dahlgren	55	Hamilton County	488
Thompsonville	56	Franklin County	476
Grand Tower	57	Jackson County	474
Mound City	58	Pulaski County	461
Dix	59	Jefferson County	451
Ullin	60	Pulaski County	450
Waltonville	61	Jefferson County	395
Whiteash	62	Williamson County	394
Buckner	63	Franklin County	393
Karnak	64	Pulaski County	392
Dowell	65	Jackson County	367
Crab Orchard	66	Williamson County	365
Bonnie	67	Jefferson County	360
Tamms	68	Alexander County	350
Cutler	69	Perry County	349
Jeffersonville	70	Wayne County	347
Blairsville	71	Jackson County	343
Olive Branch	72	Alexander County	343
Joppa	73	Massac County	324
Orient	74	Franklin County	317
Hanaford	75	Franklin County	312
Campbell Hill	76	Jackson County	306
Alto Pass	77	Union County	301
Belle Rive	78	Jefferson County	296
Ewing	79	Franklin County	292
Raleigh	80	Saline County	273
Freeman Spur	81	Williamson County	269
Opdyke	82	Jefferson County	265
Olmsted	83	Pulaski County	258
Vergennes	84	Jackson County	237
East Cape Girardeau	85	Alexander County	236
Bush	86	Jackson County	235
Cypress	87	Johnson County	219
Elizabethtown	88	Hardin County	219
Cave-In-Rock	89	Hardin County	217
Stonefort	90	Saline County	217
McClure	91	Alexander County	210
Buncombe	92	Johnson County	207
Nason	93	Jefferson County	194
Unity	94	Alexander County	188
Broughton	95	Hamilton County	177
Spillertown	96	Williamson County	175
Colp	97	Williamson County	173
Gorham	98	Jackson County	171
Thebes	99	Alexander County	170
Sims	100	Wayne County	168
New Minden	101	Perry County	161
St. Johns	102	Jackson County	154
New Burnside	103	Johnson County	152
New Grand Chain	104	Massac County	141
Pulaski	105	Pulaski County	138
Eddyville	106	Pope County	96
Mount Erie	107	Wayne County	94
Belknap	108	Johnson County	86
Johnsonville	109	Wayne County	70
Mulkeytown	110	Franklin County	63
Golden Gate	111	Wayne County	61
Muddy	112	Saline County	56
Mill Creek	113	Pulaski County	55
Keenes	114	Wayne County	49
Belle Prairie City	115	Hamilton County	45
Simpson	116	Johnson County	44
Macedonia	117	Hamilton County	29

City

Rank

County

2026 Pop. ↓

22,203

17,116