21 cities
| City | Rank | 2025 Pop. ↓ | 2020 Pop. | Annual Change | Density | Area (mi²) | Type |
|---|---|---|---|---|---|---|---|
| Harrisburg | 1 | 9,612 | 10,068 | -0.71% | 264 | 36 | Township |
| Harrisburg | 2 | 7,858 | 8,253 | -1% | 1,188 | 7 | City |
| East Eldorado | 3 | 5,161 | 5,414 | -0.75% | 142 | 36 | Township |
| Eldorado | 4 | 3,545 | 3,732 | -1.06% | 1,416 | 3 | City |
| Carrier Mills | 5 | 2,212 | 2,313 | -0.67% | 60 | 37 | Township |
| Carrier Mills | 6 | 1,584 | 1,662 | -1% | 1,311 | 1 | Village |
| Independence | 7 | 1,123 | 1,179 | -0.88% | 30 | 37 | Township |
| Raleigh | 8 | 1,061 | 1,107 | -0.56% | 29 | 36 | Township |
| Galatia | 9 | 1,049 | 1,098 | -0.66% | 56 | 19 | Township |
| Brushy | 10 | 942 | 987 | -0.63% | 28 | 34 | Township |
| Galatia | 11 | 778 | 821 | -1.14% | 399 | 2 | Village |
| Stonefort | 12 | 361 | 373 | -0.55% | 21 | 18 | Township |
| Mountain | 13 | 347 | 366 | -0.86% | 8 | 42 | Township |
| Tate | 14 | 276 | 291 | -0.72% | 15 | 18 | Township |
| Raleigh | 15 | 275 | 288 | -1.08% | 139 | 2 | Village |
| Long Branch | 16 | 239 | 249 | -0.42% | 13 | 18 | Township |
| Stonefort | 17 | 218 | 223 | -0.46% | 150 | 1 | Village |
| Cottage | 18 | 217 | 228 | -0.46% | 7 | 31 | Township |
| Eldorado | 19 | 131 | 135 | -1.5% | 4 | 36 | Township |
| Rector | 20 | 64 | 68 | -1.54% | 4 | 18 | Township |
| Muddy | 21 | 56 | 59 | -1.75% | 185 | 0 | Village |
Harrisburg is the largest city in Saline County, with a population of 9,612.
Muddy is the smallest city in Saline County, with a population of 56.
There are 21 cities in Saline County, Illinois.