| City | Rank | 2026 Pop. ↓ | 2020 Pop. | Annual Change | Density (/mi²) | Area (mi²) | Type |
|---|---|---|---|---|---|---|---|
| Vincennes | 1 | 16,295 | 16,761 | -0.51% | 2,186 | 7 | City |
| Bicknell | 2 | 2,972 | 3,033 | -0.34% | 2,197 | 1 | City |
| Oaktown | 3 | 575 | 578 | -0.17% | 2,114 | 0 | Town |
| Monroe City | 4 | 485 | 492 | -0.41% | 1,803 | 0 | Town |
| Bruceville | 5 | 447 | 450 | -0.22% | 1,303 | 0 | Town |
| Wheatland | 6 | 390 | 393 | -0.26% | 951 | 0 | Town |
| Sandborn | 7 | 358 | 362 | -0.28% | 918 | 0 | Town |
| Edwardsport | 8 | 275 | 281 | -0.36% | 979 | 0 | Town |
| Decker | 9 | 197 | 198 | 0% | 1,048 | 0 | Town |
Vincennes is the largest city in Knox County, with a population of 16,295.
Decker is the smallest city in Knox County, with a population of 197.
There are 9 cities in Knox County, Indiana.