14 cities
| City | Rank | 2025 Pop. ↓ | 2020 Pop. | Annual Change | Density | Area (mi²) | Type |
|---|---|---|---|---|---|---|---|
| Flatwoods | 1 | 7,236 | 7,316 | -0.19% | 2,069 | 3 | City |
| Flatwoods | 2 | 7,236 | 7,303 | -0.19% | 2,069 | 3 | City |
| Russell | 3 | 3,613 | 3,747 | -0.69% | 949 | 4 | City |
| Russell | 4 | 3,613 | 3,737 | -0.69% | 949 | 4 | City |
| Raceland | 5 | 2,291 | 2,343 | -0.43% | 923 | 2 | City |
| Raceland | 6 | 2,291 | 2,338 | -0.43% | 923 | 2 | City |
| Worthington | 7 | 1,440 | 1,504 | -0.83% | 1,268 | 1 | City |
| Worthington | 8 | 1,440 | 1,498 | -0.83% | 1,268 | 1 | City |
| Greenup | 9 | 1,071 | 1,114 | -0.74% | 618 | 2 | City |
| Greenup | 10 | 1,071 | 1,110 | -0.74% | 618 | 2 | City |
| South Shore | 11 | 1,035 | 1,070 | -0.67% | 1,470 | 1 | City |
| South Shore | 12 | 1,035 | 1,068 | -0.67% | 1,470 | 1 | City |
| Wurtland | 13 | 967 | 986 | -0.41% | 547 | 2 | City |
| Wurtland | 14 | 967 | 984 | -0.41% | 547 | 2 | City |
Flatwoods is the largest city in Greenup County, with a population of 7,236.
Wurtland is the smallest city in Greenup County, with a population of 967.
There are 14 cities in Greenup County, Kentucky.