| City | Rank | 2026 Pop. ↓ | 2020 Pop. | Annual Change | Density (/mi²) | Area (mi²) | Type |
|---|---|---|---|---|---|---|---|
| Caro | 1 | 4,246 | 4,317 | -0.28% | 1,442 | 3 | City |
| Millington | 2 | 4,159 | 4,237 | -0.29% | 117 | 36 | Township |
| Vassar | 3 | 3,867 | 3,886 | -0.1% | 110 | 35 | Township |
| Elkland | 4 | 3,474 | 3,529 | -0.32% | 99 | 35 | Township |
| Arbela | 5 | 2,760 | 2,810 | -0.36% | 82 | 33 | Township |
| Denmark | 6 | 2,694 | 2,749 | -0.37% | 76 | 35 | Township |
| Vassar | 7 | 2,675 | 2,733 | -0.37% | 1,245 | 2 | City |
| Cass City | 8 | 2,481 | 2,516 | -0.24% | 1,406 | 2 | Village |
| Indianfields | 9 | 2,455 | 2,483 | -0.32% | 78 | 31 | Township |
| Watertown | 10 | 2,072 | 2,095 | -0.1% | 64 | 33 | Township |
| Almer | 11 | 1,988 | 1,996 | -0.05% | 59 | 34 | Township |
| Tuscola | 12 | 1,912 | 1,965 | -0.47% | 58 | 33 | Township |
| Dayton | 13 | 1,896 | 1,922 | -0.26% | 53 | 36 | Township |
| Juniata | 14 | 1,543 | 1,559 | -0.19% | 44 | 35 | Township |
| Fairgrove | 15 | 1,523 | 1,552 | -0.33% | 43 | 35 | Township |
| Koylton | 16 | 1,468 | 1,483 | -0.2% | 42 | 35 | Township |
| Kingston | 17 | 1,458 | 1,476 | -0.27% | 41 | 35 | Township |
| Novesta | 18 | 1,425 | 1,441 | -0.21% | 40 | 35 | Township |
| Akron | 19 | 1,345 | 1,372 | -0.37% | 25 | 53 | Township |
| Ellington | 20 | 1,315 | 1,331 | -0.23% | 37 | 35 | Township |
| Reese | 21 | 1,261 | 1,286 | -0.32% | 933 | 1 | Village |
| Columbia | 22 | 1,200 | 1,228 | -0.41% | 33 | 36 | Township |
| Elmwood | 23 | 1,045 | 1,064 | -0.38% | 30 | 35 | Township |
| Millington | 24 | 998 | 1,025 | -0.5% | 733 | 1 | Village |
| Mayville | 25 | 900 | 921 | -0.44% | 836 | 1 | Village |
| Gilford | 26 | 721 | 739 | -0.55% | 21 | 35 | Township |
| Wisner | 27 | 593 | 604 | -0.34% | 31 | 19 | Township |
| Fairgrove | 28 | 523 | 534 | -0.38% | 467 | 1 | Village |
| Unionville | 29 | 479 | 491 | -0.42% | 510 | 1 | Village |
| Kingston | 30 | 391 | 401 | -0.51% | 384 | 1 | Village |
| Akron | 31 | 366 | 374 | -0.54% | 389 | 1 | Village |
| Gagetown | 32 | 318 | 324 | -0.31% | 324 | 1 | Village |
Caro is the largest city in Tuscola County, with a population of 4,246.
Gagetown is the smallest city in Tuscola County, with a population of 318.
There are 32 cities in Tuscola County, Michigan.