| City | Rank | 2026 Pop. ↓ | 2020 Pop. | Annual Change | Density (/mi²) | Area (mi²) | Type |
|---|---|---|---|---|---|---|---|
| Muscatine | 1 | 23,051 | 23,783 | -0.49% | 1,267 | 18 | City |
| West Liberty | 2 | 3,685 | 3,849 | -0.86% | 2,085 | 2 | City |
| Wilton | 3 | 2,892 | 2,918 | 0% | 1,407 | 2 | City |
| Fruitland | 4 | 909 | 957 | -0.87% | 506 | 2 | City |
| Conesville | 5 | 351 | 355 | -0.28% | 978 | 0 | City |
| Nichols | 6 | 311 | 328 | -0.96% | 1,364 | 0 | City |
| Atalissa | 7 | 282 | 296 | -0.7% | 2,029 | 0 | City |
| Stockton | 8 | 169 | 176 | -1.17% | 1,550 | 0 | City |
| Maysville | 9 | 155 | 155 | -0.64% | 566 | 0 | City |
| Welton | 10 | 122 | 128 | -0.81% | 464 | 0 | City |
Muscatine is the largest city in Muscatine County, with a population of 23,051.
Welton is the smallest city in Muscatine County, with a population of 122.
There are 10 cities in Muscatine County, Iowa.