| City | Rank | 2026 Pop. ↓ | 2020 Pop. | Annual Change | Density (/mi²) | Area (mi²) | Type |
|---|---|---|---|---|---|---|---|
| Corydon | 1 | 1,720 | 1,524 | 0.53% | 1,258 | 1 | City |
| Seymour | 2 | 643 | 636 | 0.31% | 269 | 2 | City |
| Humeston | 3 | 473 | 466 | 0.42% | 758 | 1 | City |
| Allerton | 4 | 430 | 429 | 0.23% | 362 | 1 | City |
| Lineville | 5 | 192 | 191 | 0% | 213 | 1 | City |
| Promise City | 6 | 90 | 89 | 0% | 489 | 0 | City |
| Clio | 7 | 67 | 66 | 0% | 90 | 1 | City |
| Millerton | 8 | 38 | 38 | 0% | 130 | 0 | City |
Corydon is the largest city in Wayne County, with a population of 1,720.
Millerton is the smallest city in Wayne County, with a population of 38.
There are 8 cities in Wayne County, Iowa.