Southeast Missouri Cities

164 cities

City
Rank
County
2025 Pop. ↓
Cape Girardeau1Cape Girardeau County40,992
Farmington2St. Francois County18,775
Poplar Bluff3Butler County16,084
Sikeston4Scott County15,967
Jackson5Cape Girardeau County15,939
West Plains6Howell County12,862
Kennett7Dunklin County9,869
Park Hills8St. Francois County8,864
Perryville9Perry County8,471
Dexter10Stoddard County7,834
Bonne Terre11St. Francois County6,294
Caruthersville12Pemiscot County5,022
Desloge13St. Francois County4,897
Salem14Dent County4,759
Fredericktown15Madison County4,574
Charleston16Mississippi County4,397
Scott City17Scott County4,352
Malden18Dunklin County3,407
Cuba19Crawford County3,217
Chaffee20Scott County3,006
East Prairie21Mississippi County2,825
Mountain View22Howell County2,705
Portageville23New Madrid County2,657
New Madrid24New Madrid County2,526
Willow Springs25Howell County2,243
Hayti26Pemiscot County2,200
Thayer27Oregon County1,913
Piedmont28Wayne County1,843
Bernie29Stoddard County1,820
Doniphan30Ripley County1,814
Bloomfield31Stoddard County1,726
Steele32Pemiscot County1,637
Bourbon33Crawford County1,505
Campbell34Dunklin County1,475
Senath35Dunklin County1,472
Ironton36Iron County1,435
Steelville37Crawford County1,427
Marble Hill38Bollinger County1,371
Advance39Stoddard County1,326
Indian Lake40Crawford County1,250
Bismarck41St. Francois County1,240
Oran42Scott County1,208
Leadwood43St. Francois County1,161
Winona44Shannon County1,001
Benton45Scott County935
Clarkton46Dunklin County923
Miner47Mississippi County893
Lilbourn48New Madrid County888
Puxico49Stoddard County853
Van Buren50Carter County768
Leadington51St. Francois County767
Ellington52Reynolds County760
Doe Run53St. Francois County759
Alton54Oregon County707
Morley55Scott County699
Gideon56New Madrid County696
Bertrand57Mississippi County691
Pilot Knob58Iron County688
Morehouse59New Madrid County667
Viburnum60Iron County653
Iron Mountain Lake61Iron County648
Gordonville62Cape Girardeau County627
Arcadia63Iron County602
Doolittle64Dent County578
Holcomb65Dunklin County577
Birch Tree66Shannon County566
Shakertowne67Bollinger County565
Kelso68Scott County548
Eminence69Shannon County531
Cardwell70Dunklin County513
Parma71New Madrid County496
Matthews72New Madrid County490
Hornersville73Dunklin County489
Qulin74Butler County468
Hayti Heights75Pemiscot County457
Bell City76Stoddard County454
Naylor77Ripley County450
Greenville78Wayne County436
Ellsinore79Carter County426
Essex80Stoddard County395
Oak Grove Village81Crawford County394
Millersville82Cape Girardeau County387
Arbyrd83Dunklin County382
Delta84Cape Girardeau County375
Marston85New Madrid County356
Fairdealing86Ripley County345
Altenburg87Cape Girardeau County337
Leasburg88Crawford County311
Neelyville89Butler County311
Fisk90Butler County309
Cooter91Pemiscot County306
Bunker92Reynolds County295
Junction City93Madison County281
West Sullivan94Crawford County277
Wardell95Pemiscot County271
Williamsville96Wayne County270
Cobalt97Madison County262
Dutchtown98Cape Girardeau County260
Risco99New Madrid County253
Howardville100New Madrid County247
Annapolis101Iron County244
Frohna102Perry County243
Oak Ridge103Cape Girardeau County238
Grandin104Carter County231
New Hamburg105Scott County231
Perkins106Scott County225
Shawneetown107Cape Girardeau County215
Wyatt108Mississippi County209
Mine La Motte109Madison County208
Blodgett110Scott County204
Koshkonong111Oregon County200
Pomona112Howell County196
Whiting113Mississippi County190
Vanduser114Scott County189
Marquand115Madison County188
Sedgewickville116Bollinger County187
Cherokee Pass117Madison County186
Anniston118Mississippi County176
Holland119Pemiscot County172
Burfordville120Cape Girardeau County161
Centerville121Reynolds County161
Diehlstadt122Mississippi County155
Mill Spring123Wayne County155
Canalou124New Madrid County145
Haywood City125Cape Girardeau County135
Brandsville126Howell County130
Des Arc127Iron County128
Denton128Dunklin County124
Miramiguoa Park129Crawford County123
Dudley130Stoddard County100
Frankclay131St. Francois County100
Wortham132St. Francois County96
Allenville133Cape Girardeau County94
Pocahontas134Cape Girardeau County94
Montier135Shannon County91
Longtown136Bollinger County90
Hunter137Carter County87
Zalma138Bollinger County86
Whitewater139Cape Girardeau County85
Pascola140Pemiscot County80
Deering141Pemiscot County76
Wilson City142Mississippi County73
Frisbee143Dunklin County72
Old Appleton144Cape Girardeau County71
Tallapoosa145New Madrid County70
Broseley146Butler County69
Homestown147Pemiscot County68
White Oak148Dunklin County64
Glen Allen149Bollinger County60
Bragg City150Pemiscot County59
Lithium151Bollinger County59
South Fork152Howell County51
Grayridge153Stoddard County50
Penermon154Stoddard County48
Biehle155Bollinger County46
New Wells156Cape Girardeau County41
Rives157Dunklin County41
Commerce158Scott County40
St. Cloud159Crawford County40
Catron160New Madrid County37
Hayward161New Madrid County27
Knob Lick162St. Francois County24
North Lilbourn163New Madrid County20
Oxly164Ripley County11