| City | Rank | 2026 Pop. ↓ | 2020 Pop. | Annual Change | Density (/mi²) | Area (mi²) | Type |
|---|---|---|---|---|---|---|---|
| Bloomsburg | 1 | 13,541 | 12,704 | 1.24% | 3,114 | 4 | Town |
| Berwick | 2 | 10,290 | 10,321 | -0.07% | 3,347 | 3 | Borough |
| Scott | 3 | 5,656 | 5,509 | 0.07% | 813 | 7 | Township |
| Briar Creek | 4 | 3,055 | 2,997 | 0.36% | 146 | 21 | Township |
| Berwick | 5 | 2,488 | 2,402 | 0.53% | 323 | 8 | Township |
| Hemlock | 6 | 2,360 | 2,214 | 1.46% | 134 | 18 | Township |
| North Centre | 7 | 2,174 | 2,035 | 1.64% | 145 | 15 | Township |
| South Centre | 8 | 1,933 | 1,906 | 0.21% | 356 | 5 | Township |
| Greenwood | 9 | 1,914 | 1,878 | 0.31% | 68 | 28 | Township |
| Benton | 10 | 1,767 | 1,716 | 0.86% | 73 | 24 | Township |
| Fishing Creek | 11 | 1,589 | 1,523 | 0.76% | 56 | 28 | Township |
| Catawissa | 12 | 1,538 | 1,540 | -0.06% | 2,998 | 1 | Borough |
| Locust | 13 | 1,460 | 1,438 | 0.27% | 82 | 18 | Township |
| Benton | 14 | 1,381 | 1,315 | 1.02% | 70 | 20 | Township |
| Main | 15 | 1,296 | 1,270 | 0.47% | 80 | 16 | Township |
| Montour | 16 | 1,261 | 1,255 | 0.08% | 138 | 9 | Township |
| Orange | 17 | 1,194 | 1,159 | 0.84% | 93 | 13 | Township |
| Cleveland | 18 | 1,157 | 1,134 | 0.26% | 50 | 23 | Township |
| Pine | 19 | 1,026 | 1,010 | 0.29% | 39 | 26 | Township |
| Millville | 20 | 981 | 975 | 0.1% | 1,000 | 1 | Borough |
| Catawissa | 21 | 917 | 908 | -0.11% | 74 | 12 | Township |
| Benton | 22 | 818 | 822 | -0.12% | 1,370 | 1 | Borough |
| Briar Creek | 23 | 610 | 596 | 0.33% | 369 | 2 | Borough |
| Roaring Creek | 24 | 566 | 559 | 0.18% | 24 | 23 | Township |
| Orangeville | 25 | 475 | 477 | -0.21% | 1,067 | 0 | Borough |
| New Columbus | 26 | 224 | 218 | 0.45% | 72 | 3 | Borough |
| Stillwater | 27 | 198 | 199 | -0.5% | 64 | 3 | Borough |
| Centralia | 28 | 4 | 4 | 0% | 17 | 0 | Borough |
Bloomsburg is the largest city in Columbia County, with a population of 13,541.
Centralia is the smallest city in Columbia County, with a population of 4.
There are 28 cities in Columbia County, Pennsylvania.