Upstate South Carolina Cities

City
Rank
County
2026 Pop. ↓
Greenville1Greenville County76,180
Greer2Greenville County52,676
Spartanburg3Spartanburg County40,261
Mauldin4Greenville County32,739
Anderson5Anderson County31,715
Simpsonville6Greenville County29,612
Easley7Pickens County28,302
Taylors8Greenville County24,163
Greenwood9Greenwood County22,796
Wade Hampton10Greenville County20,722
Five Forks11Greenville County20,236
Clemson12Pickens County19,149
Berea13Anderson County17,184
Fountain Inn14Greenville County15,551
Gantt15Greenville County15,248
Powdersville16Anderson County13,934
Boiling Springs17Spartanburg County13,622
Parker18Greenville County12,825
Gaffney19Cherokee County12,538
Seneca20Oconee County9,515
Travelers Rest21Greenville County9,428
Laurens22Laurens County9,326
Sans Souci23Greenville County8,275
Union24Union County8,033
Clinton25Laurens County7,972
Clemson University26Anderson County7,919
Welcome27Anderson County7,617
Valley Falls28Spartanburg County7,468
Lyman29Spartanburg County7,296
Homeland Park30Anderson County7,094
Centerville31Anderson County6,923
Woodruff32Spartanburg County6,237
Piedmont33Greenville County5,944
Central34Pickens County5,309
Abbeville35Abbeville County4,910
Duncan36Spartanburg County4,802
Belton37Anderson County4,692
Whitney38Spartanburg County4,503
Williamston39Anderson County4,396
Walhalla40Oconee County4,366
Saxon41Spartanburg County4,304
Keowee Key42Oconee County4,070
Southern Shops43Spartanburg County4,035
Wellford44Spartanburg County4,020
Honea Path45Anderson County4,003
Northlake46Anderson County3,872
Pendleton47Anderson County3,790
Hilltop48Spartanburg County3,764
Roebuck49Spartanburg County3,761
Dunean50Greenville County3,726
Arkwright51Spartanburg County3,582
Inman52Spartanburg County3,550
Liberty53Pickens County3,336
Golden Grove54Anderson County3,226
Pickens55Pickens County3,194
East Gaffney56Cherokee County3,188
Landrum57Spartanburg County2,942
Ben Avon58Spartanburg County2,873
Arcadia59Spartanburg County2,745
Pacolet60Spartanburg County2,715
Westminster61Oconee County2,528
Watts Mills62Laurens County2,392
Cowpens63Spartanburg County2,309
Judson64Greenville County2,236
Tigerville65Greenville County2,103
Ninety Six66Greenwood County2,092
Mayo67Spartanburg County2,049
Blacksburg68Cherokee County1,982
Camp Croft69Spartanburg County1,974
Reidville70Spartanburg County1,958
Arial71Pickens County1,904
Slater-Marietta72Greenville County1,878
Monarch Mill73Union County1,832
Calhoun Falls74Abbeville County1,788
Ware Shoals75Greenwood County1,739
Fairforest76Spartanburg County1,715
Utica77Oconee County1,538
Pelzer78Anderson County1,453
Conestee79Greenville County1,446
Joanna80Laurens County1,337
Due West81Abbeville County1,315
Drayton82Spartanburg County1,284
Lake Secession83Abbeville County1,238
Iva84Anderson County1,225
Buffalo85Union County1,224
Cateechee86Anderson County1,216
Sandy Springs87Anderson County1,175
City View88Greenville County1,132
La France89Anderson County1,126
West Pelzer90Anderson County1,052
The Cliffs Valley91Greenville County1,001
Chesnee92Spartanburg County984
Clifton93Spartanburg County935
Chickasaw Point94Anderson County898
Inman Mills95Spartanburg County860
Gray Court96Laurens County819
Jonesville97Union County810
Campobello98Spartanburg County803
Six Mile99Pickens County771
Norris100Pickens County762
Modoc101McCormick County659
Fair Play102Oconee County553
Cross Hill103Laurens County445
Newry104Oconee County444
Enoree105Spartanburg County427
South Union106Anderson County410
West Union107Oconee County399
Converse108Spartanburg County382
Cokesbury109Abbeville County370
Lockhart110Union County366
Mount Carmel111McCormick County366
Carlisle112Union County319
Donalds113Abbeville County318
Startex114Spartanburg County315
Pauline115Spartanburg County314
Antreville116Abbeville County279
Dacusville117Pickens County266
Fingerville118Spartanburg County262
Central Pacolet119Cherokee County253
Bradley120Greenwood County216
Glenn Springs121Spartanburg County213
Starr122Anderson County182
Hodges123Greenwood County161
Waterloo124Laurens County160
Glendale125Spartanburg County142
Parksville126McCormick County133
Salem127Oconee County130
Lowndesville128Abbeville County121
Gramling129Spartanburg County110
Princeton130Abbeville County108
Mountville131Laurens County98
Troy132Greenwood County87
Tamassee133Oconee County82
Cross Anchor134Spartanburg County80
Plum Branch135McCormick County80
Ware Place136Anderson County72
Clarks Hill137McCormick County66
Caesars Head138Greenville County46
Promised Land139Abbeville County38
Cherokee Falls140Cherokee County34
Longcreek141Oconee County32
Coronaca142Abbeville County13

About Upstate South Carolina

Sources

  1. US Census: 2025 Gazetteer Files
  2. City and Town Population Totals: 2020-2024